Bram Stokers Dracula Compared to Mary Shellys Frankenstein Free Essay Example, 1250 words

Even though Shelley did give the monster the latitude to express his pains, but they were all told from the viewpoint of the primary character, Victor, who had complete authority over manipulating the monster’s side as well. The Dracula too is completely told from the protagonist’s perspective and the character develops through the character’s exchanges. Despite the fact that both novels follow the same thematic pattern with a hint of supernatural, tragedy and an epic battle between good and evil, but the differences are still quite ostensible. II. Differences There is a strong divergence in how both stories progress, even though they belong to the same genre. As a matter of fact, the way the author has depicted and interpreted the antagonists’ motives is also quite different. For instance, Dracula and Frankenstein are supernatural beings, but the former is a damned creature for eternity, whereas the latter is a faulty creation of man. Count Dracula is a blood-sucking monster by night and a refined Transylvanian count by day, who is trying to climb up the social ladder in England. Unlike Dracula, Frankenstein’s creation has a monstrous exterior regardless of the time of the day, with a gigantic body that the scientist assembled using the limbs and parts of dead animals and humans. We will write a custom essay sample on Bram Stoker's Dracula Compared to Mary Shelly's Frankenstein or any topic specifically for you Only $17.96 $11.86/pageorder now It can be postulated that Dracula was a creature who embodied satanic traits and was portrayed as being evil to the core, whereas, Frankenstein was in fact misunderstood throughout the course of the story. Born as a failed experiment, he was rejected by his maker and was forced to seek refuge in the wilderness. He teaches himself how to read and write, in an attempt to ferret out a way to fit in the society, but to his dismay he is welcomed by shrieks; his presence only evoking terror and horror amongst others. Constant rejection often causes him to lose control and as a result he starts killing people in revenge, but that is only because he is unable to channel his emotions effectively and in the end it is obvious that the monster is lonely. He recalls, â€Å"There was none among the myriads of men that existed who would pity or assist me; and should I feel kindness towards my enemies? No; from that moment I declared everlasting war against the species, and more than all, against him who had formed me and sent me forth to this insupportable misery† (Shelley, 2004, pp. 137-138). On the other hand, Dracula had social acceptance and was a respected member of the society. His knowledge added to his charm and charisma that drew people towards him; even without using his telepathic skil ls, he is depicted as having a way with people that made others want to do his biddings.

The Greatest Composer Ever By Wolfgang Amadeus Mozart

Fur Elise, Moonlight Sonata, Emperor Concerto, Pathetique and Violin Concerto all share a common trait. If you said Ludwig van Beethoven, you would be correct. One of the greatest composer ever, only to be rivaled by Wolfgang Amadeus Mozart. He happened to be deaf when he created many of his famous works. Today, I am going to tell you about his childhood, early life, then to his later stages in life where he was deaf. But it was when he became deaf, he produced his greatest works of music. Ludwig was baptized on December 17, 1770 in Bonn Germany. Many believe that he was actually born on the 16th, as babies during his time were baptized within 24 hours. Out of the seven children that his parents had, only three sons survived. Ludwig being the eldest of the three. His first teacher was his father, who was a singer in Court at Bonn. He noticed early on that Ludwig had an incredible musical talent. He saw him as the next Mozart. His father, Johann van Beethoven would practice with Beet hoven day and night. There have been records from neighbors that say they saw Johann beat Ludwig when he missed a note, or hesitated (Bio, 2016). His father was very cruel to him, and a very much so an alcoholic. Ludwig was so talented that his father forced him to perform at the age of seven. Though he when he show was being advertised, it was called the â€Å"little son of six years† (which was the age that Mozart first performed in front of Empress Maria Theresia). Beethoven always struggledShow MoreRelated Life Of Mozart Essay670 Words   |  3 Pages The Life of Wolfgang Amadeus Mozart nbsp;nbsp;nbsp;nbsp;nbsp;Wolfgang Amadeus Mozart (1756-91) is regarded as the greatest composer who ever lived. He began writing minuets at the age of 5,and by the time he died in 1791 at the age of 35, he had produced 626 cataloged works. â€Å" Mozart has enriched the concerto form with a larger number of masterpieces than any other composer.†1 nbsp;nbsp;nbsp;nbsp;nbsp;Wolfgang Amadeus Mozart is said to be the greatest genius in western music history.Read More Life of Mozart Essays2866 Words   |  12 PagesCharacter A.  Ã‚  Ã‚  Ã‚  Ã‚  Influences on Other Composers B.  Ã‚  Ã‚  Ã‚  Ã‚  Personality Issues C.  Ã‚  Ã‚  Ã‚  Ã‚  Relationships D.  Ã‚  Ã‚  Ã‚  Ã‚  Music To Boost Brain Power E.  Ã‚  Ã‚  Ã‚  Ã‚  Study of Rats and Mozart F.  Ã‚  Ã‚  Ã‚  Ã‚  Ending Conclusion III.  Ã‚  Ã‚  Ã‚  Ã‚  Assessment and Evaluation A. Greatness of a Man B.  Ã‚  Ã‚  Ã‚  Ã‚   His Ideals C.  Ã‚  Ã‚  Ã‚  Ã‚   Mozart and Saleiri D. The Legacy Lives On. Chapter I Mozart’s Prodigious Life   Ã‚  Ã‚  Ã‚  Ã‚  Without a doubt, Wolfgang Amadeus Mozart born January 27, 1756, in Salzburg, was probably the greatest genius in Western musical historyRead More wolfgang amadeus mozart Essay1190 Words   |  5 Pages Mozart was considered to be the best musician/composer of all time. Mozart was a genius when it came music and composing, he was said that no other could rival him and to this day people still say that he is the best. The reason why I choose to do Mozart is the fact I do believe he is the best musician/composer of all time, and his life story is of a tragic but gifted young soul. Later on you will find out about his family, his teachings, his tragedies, and of course his accomplishments. WolfgangRead MoreThe Classical Era Of Music1012 Words   |  5 Pagesand during that time many great composers rose including Franz Joseph Haydn, Wolfgang Amadeus Mozart, and Ludwig Van Beethoven. A very important composer whose music is still heard today is Wolfgang Amadeus Mozart. His fame and great works in music changed throughout his childhood, middle age, and his final years. Wolfgang Amadeus Mozart was born in Salzburg, Austria January 27, 1756. His father Leopold Mozart was a violinist to the court. Wolfgang Amadeus Mozart was the child that Leopold wasRead MoreThe Aesthetic Qualities Of A Musical Selection From Space Odyssey1568 Words   |  7 Pagesunderstand what composers were trying to accomplish with their music. I will discuss an influential composer and his musical time period, along with events that helped shape his career. I will also cover a musical period that I believe to be most important to music history. I would also like to discuss how this course has influenced the way I listen and hear music. Lastly, I will analyze the aesthetic qualities of a musical selection from Space Odyssey: 2001. Wolfgang Amadeus Mozart A prolific artistRead MoreWolfgang Amadeus Mozart s Overture945 Words   |  4 PagesWolfgang Amadeus Mozart’s overture to The Marriage of Figaro brings together all the components and styles of the classical period. With it being an overture, it sets the mood and allows people to get ready for the opera they are about to watch. Mozart was one of the greatest composers to ever resonate from the classical period and his music is still studied and played worldwide today. Wolfgang Amadeus Mozart was born in 1756 in Salzburg. (Kem) Recognized for his works at an extremely young ageRead More Mozart Essay920 Words   |  4 Pages Wolfgang Amadeus Mozart is one of the greatest music composers who ever lived. His name and the word genius are often bandied about together by music writers and critics and many would argue rightly so. Mozart had a fantastic ear for writing a catchy tune with perfect orchestral arrangement. His compositions have a rich and distinctive sound; it can be said that in his brief lifetime (only 35 years) that he wrote a masterpiece in every genre of classical music without much apparent effort. OriginalRead MoreWolfgang Amadeus Mozart : An Influential Composer1948 Words   |  8 PagesWolfgang Amadeus Mozart Johannes Chrysostomus Wolfgangus Theophilus Mozart, or Wolfgang Amadeus Mozart as he was more commonly known, is one of the most influential composers to ever live. His incredible success during the Classical Period has brought him lots of attention from everyone from classical music listeners to classical music scholars and performers. Childhood and Early Career Mozart was born on January 27, 1756, in Salzburg, Austria to Leopold Mozart and Anna Maria Pertyl. His fatherRead More Wolfgang Amadeus Mozart Essay1138 Words   |  5 PagesWolfgang Amadeus Mozart Mozart is perhaps the greatest musical genius who ever lived. Mozart s full name is Wolfgang Amadeus Mozart. Most people called him Mozart or Wolfgang. Mozart was born in Salzburg, Austria, January 27, 1756. His father, Leopold, perhaps the greatest influence on Mozarts life, was the vice Kapellmeister (assistant choir director) to the Archbishop of Salzburg at the time of Mozarts birth. Mozart was actually christened as Joannes Chrysotomus Wolfgangus Theophilus,Read MoreMozart vs. Beethoven Essay1275 Words   |  6 PagesArts and Culture 2 Mozart vs. Beethoven Paper 3/21/12 Mozart vs. Beethoven In the 18th century, the middle class made a lot more money. During the Classical Period, the middle class had a tremendous influence on music. They wanted to hear concertos and symphonies. They wanted their children to learn great music and play instruments. The composers began writing music that was geared towards the middle class because they could make a better living if they enjoyed the music being played. They

Programm Free Essays

Programming exercises 1. Consider the following incomplete C++ program #include int main() { †¦. } a. We will write a custom essay sample on Programm or any similar topic only for you Order Now Write a statement that include the header files fstream, string, and iomanip in this program. b. Write statements that declare inFile to be an ifstream variable and outFile to be an ofstream variable. c. The program will read data from the file inData. txt and write output to the file outData. txt. Write statements to open both of these files, associate inFile with inData. txt, and associate outFile with outData. txt. . Suppose that the file inData. txt contains the following data: 10. 20 5. 35 15. 6 Randy Gill 31 18500 3. 5 A The numbers in the first line represent the length and width, respectively, of a rectangle. The number in the second line represents the radius of a circle. The third line contains the first name, last name, and the age of a person. The first number in the fourth line is the savings account balance at the beginning of the month, and the second number is the interest rate per year. (Assume thatp = 3. 1416. The fifth line contains an uppercase letter between A a nd Y (inclusive). Write statements so that after the program executes, the contents of the file outData. txt are as shown below. If necessary, declare additional variables. Your statements should be general enough so that if the content of the input file changes and the program is run again(without editing and recompiling), it outputs the appropriate results. Rectangle: Length = 10. 20, width = 5. 35, area = 54. 57, parameter = 31. 10 Circle: Radius = 15. 60, area = 764. 4, circumference = 98. 02 Name: Randy Gill, age: 31 Beginning balance = $18500. 00, interest rate = 3. 50 Balance at the end of the month = $18553. 96 The character that comes after A in the ASCII set is B e. Write statements that close the input and output files. f. Write a C++ program that tests the statements in parts a through e. 4. During each summer, John and Jessica grow vegetables in their back yard and buy seeds and fertilizer from a local nursery. The nursery carries different types of vegetable fertilizer s in various bag sizes. When buying a particular fertilizer, they want to know the price of the fertilizer per pound and the cost of fertilizing per square foot. The following program prompts the user to enter the size of the fertilizer bag, in pounds, the cost of bag, and the area in square feet, that can be covered by the bag. The program should output the desired result. However, the program contains logical errors. Find and correct the logic errors so that the program works properly. // Logic Errors #include #include iomanip using namespace std; int main() { double cost; double area; Double bagSize cout How to cite Programm, Essay examples

Early Childhood Education and Care Knowledge and Skills

Question: Discuss about the Early Childhood Education and Care for Knowledge and Skills. Answer: Introduction Education is not just a simple source of getting knowledge, skills and information, but the most important factor about getting education is being an educated person. The role of kindergarten teachers is very important. This is the age where childrens skills and talent can be encouraged and polished. The role of teachers is to monitor children, understanding their state of mind, and setting educational goals on the basis of their mental and physical level. Attendance is also an important factor for children in Kindergarten. Absenteeism can be a big issue for the academic and mental education of a child. The essay will discuss the problem of absenteeism in the kindergarten school and its effect on their educational, social and emotional development. Different studies have described that higher attendance is related to more success in education and achievement in academics. The essay will discuss the case study of 6 years old child, who is very active and intelligent. His sense of self and morals is very high, which is usually not found in children of his age. Problem Found The six years old boy in the class is very active and smart. He is a very talented and gifted boy. He knows the name of the planet can easily draw them with their names and position in solar system. He is a very challenging boy for teachers, as he asks lot of questions and is very curious about everything. His learning skills and capabilities are also very good, as he can learn quickly and efficiently. He has a very large vocabulary in comparison to other children of his age, and he also makes good grades in all subjects. While answering questions, he is always very alert and uses a lot of common sense. He is also very good at absorbing new information and remembering them. His perspective towards world is very big and ask bigger questions related to world and universe that usually children of his age do not ask such questions. The child is also very sensitive and has great sense of right and wrong. He prefers reading books and magazines written for older children, but the main probl em with the child is absenteeism. He is not regular with school and has chronic absenteeism. The logic presented by the child is often above his age. He tries to find logic behind every single thing that could pose difficulty in his future life. Highly logically people often detach from emotions and understanding. According to the study of Rasasingham (2015), absenteeism is a major issue that requires attention, as it increases the chances of school dropout. It is also the predicator of many issues that can last till adulthood. The 6 years child is very bright and smart; he can lose his creativity and curiosity by absenteeism. Early absenteeism is also associated with school based education and health programs. This can result in leading the child towards economical deprivation and many psychiatric, social and marital problems (Kearney and Graczyk, 2014). Absenteeism can be a major issue for children, though it can be seen as the temperory problem, but prolonged absenteeism can be a predicator of lasting issues (Kearney and Graczyk, 2014). Absenteeism can result in to different mental issues. Child can lose his knowledge, grasping power and social interaction. Absenteeism can result in to serious issues in adulthood, as it can be associated with suicide attempts, teenage perilous sexual behavior, unintentional injuries, increase alcoholism and substance abuse (Kearney, 2008). Problem of Absenteeism The problem of absenteeism is very broad and the early definition of absenteeism states that it is related to school phobia, difficulty to adjust in school and anxiety. According to the definition of Absenteeism given by Kearney (2008), it is a legitimate or illegitimate absence from school or class. Legitimate reasons for missing school include illnesses, religious holidays, the need to attend a family funeral, hazardous weather conditions, and exemptions for college attendance or specific kinds of work (p. 452). Absenteeism is also caused due to School refusal behaiour. Such behavior is child motivated, where he refuses to attend school. Such behavior is different from unlawful absenteeism, which is done without knowledge of parents (Haarman, 2011). But, here the main concern is the absenteeism as school refusal behavior. Here the parents of the child are aware of this behavior of their son. Attempt to Alleviate the Problem by Trying out Various Strategies/Methods The major problem with the children with absenteeism is psychological and physical conditions. If the child is displaying chronic absenteeism, than he is more likely to suffer with anxiety, disruptive behavior, and loss of interest in education (Balfanz Byrnes, 2012). Such children require attention of the patents and teachers. Special strategies are required to be applied with combined efforts of parents and teachers. Chronic absenteeism (child missing 10% of the total school days) is considered as the issue for the children of high school and college, but it is a major issue in Kindergarten (Balfanz Byrnes, 2012). Some of the strategies and methods that can be used to reduce absenteeism are: Teacher and school organization should focus on providing safe and supportive environment to the children. As, according to the case discussed, 6 years old boy is very intelligent and above the intelligence levels of his peers (Shochet et al., 2006). Such child require more focused environment. He may not be able to interact with other children due to having high sense of right and wrong. Thus, teachers require creating special environment for him, so that he can interact easily with teacher (Shochet et al., 2006). The positive environment and constructive student-teacher relationship can be considered as the protective factor for absenteeism. According to Havik, Bru Ertesvg (2014), disruptive and noisy classrooms are often disturbing for over intelligent children. They feel distracted and uninterested. Teacher in such situation focus more on disruption and forget to focus on children. Child should be involved in physical activities, art classes and other activities same like other students, as it will help him to develop social interaction, less logical and more emotional behavior. The next strategy that can be used to improve the condition of absenteeism can be the involvement and connectedness of family. Involvement of family is considered as the major protective factor for absenteeism and school truancy (Duardo, 2013). For applying this strategy, it is important to identify the socio-economic status of the family, attitude of family towards education of child, their awareness towards absenteeism, parental situation, single parent family, child abuse and parenting skills of parents (Ready, 2010). The early absenteeism can result in deteriorated academic efficiency of the child, and in the higher grades his condition could worsen (Chang and Romero, 2008). Family can be involved for pick and drop and should be educated about importance of presence in school. Child may feel more motivated with support of parents and family. Some of the factors that can increase absenteeism are alcoholic and abusive parents. Such children become very sensitive and get easily upset, which may discourage them to come to school. According to the provided case scenario, the 6 years old boy is very sensitive and get easily upset (Gottfried, 2014). He may require more protective and supportive environment at school. He is very active and smart, thus teacher should focus on answering his all questions and providing him learning stuff related to his interest. The next strategy for the child would be introducing lessons same as others, but with different assessment level. Lessons taught will be same but different assessment will help to motivate and encourage his knowledge (Bruner, Discher, Chang, 2011). His lessons will be different from others, as his intelligence level is higher than other students, so he requires more comprehensive lessons plans and activities. Assessment and activities given to him can be different from others, where he can display his broad knowledge and intelligence (Gottfried, 2014). Such change in strategies will promote and encourage his knowledge level and absenteeism can be reduced. Conclusion Early school absenteeism can be a major issue for the children and their future life. Absenteeism must be monitored and evaluated at the early level, because the chronic absenteeism can be very risky for the academic grades of the child. According to the case presented about a 6 years old child, he is very smart and intelligent. He is also very energetic, but may be very sensitive with few things. He easily gets upset that can increase absenteeism to chronic level in his condition. The essay discussed various strategies that can be used to improve his attendance in class. The major barrier to attendance can be childs own behavior, family situation, uninteresting class lessons and activities. Child is very intelligent and has broad scope of knowledge in comparison to peers. Thus, he requires special attention from teachers. Holistic approach is very important for children in kindergarten. Risk factors should be identified, which are associated with school absenteeism. Such children re quire enhanced and comprehensive lessons and leaning environment to promote knowledge and support. References Balfanz, R., Byrnes, V. (2012). The Importance of Being There: A Report on Absenteeism in the Nations Public Schools.Baltimore, MD: Johns Hopkins Univesrity School of Education, Everyone Graduates Center, Get Schooled, 1-46. Bruner, C., Discher, A., Chang, H. (2011). Chronic elementary absenteeism: A problem hidden in plain sight.Attendance Works and Child Family Policy Center. Chang, H. N., Romero, M. (2008). Present, Engaged, and Accounted for: The Critical Importance of Addressing Chronic Absence in the Early Grades. Report.National Center for Children in Poverty. Duardo, D. L. (2013). Solutions to Chronic Absenteeism: An Evaluation of a Kindergarten Attendance Improvement Program in LAUSD. Gottfried, M. A. (2014). Chronic absenteeism and its effects on students academic and socioemotional outcomes.Journal of Education for Students Placed at Risk (JESPAR),19(2), 53-75. Havik, T., Bru, E., Ertesvg, S. K. (2014). Parental perspectives of the role of school factors in school refusal.Emotional and behavioural difficulties,19(2), 131-153. Haarman, G. B. (2011). of Course: School Refusal Behavior: Children Who Cant or Wont Go to School.Addictive Behaviors,31, 149-154. Kearney, C.A. (2008) School Absenteeism and School Refusal Behaviour in Youth: A Contemporary Review. Clinical Psychology Review, 28, 451-47 Kearney, C. A., Graczyk, P. (2014, February). A response to intervention model to promote school attendance and decrease school absenteeism. InChild Youth Care Forum(Vol. 43, No. 1, pp. 1-25). Springer US. Rasasingham, R. (2015). The Risk and Protective Factors of School Absenteeism.Open Journal of Psychiatry,5(02), 195. Ready, D.D. (2010). Socioeconomic Disadvantage, School Attendance, and Early Cognitive Development: The Differential Effects of School Exposure. Sociology of Education. 83, 271-286 Shochet, I. M., Dadds, M. R., Ham, D., Montague, R. (2006). School connectedness is an underemphasized parameter in adolescent mental health: Results of a community prediction study.Journal of Clinical Child and Adolescent Psychology,35(2), 170-179.

The Theories of Maugham and Woolf free essay sample

Presents the literary perspectives of Somerset Maugham and Virginia Woolf on the purpose of human existence This paper is a comparative analysis of W. Somerset Maughams novel Of Human Bondage and Virginia Woolfs book To the Lighthouse. The author explains how each work presents a unique perspective on the purpose of the human existence evidenced through an assessment of literary approaches and biographical influences. Also considered are the literary styles, outlooks towards death and main characters. The history of English literature can be said to resemble the lineage of a family tree. As generations pass, innovative ideologies are birthed and literature offshoots into new schools of thought. While each green branch is unique in its own right, it is also indebted to all those that came before. Hence, in this way no writer is ever wholly inventive or original. Consequently, authors Virginia Woolf and W. Somerset Maugham have more in common than either would admit to. We will write a custom essay sample on The Theories of Maugham and Woolf or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page

Written Assignment On A Case Study-Rangan, V. K., Yong, S. (2011,

Written Assignment On A Case Study-Rangan, V. K., Yong, S. (2011, Written Assignment On A Case Study Coracle Marketing al affiliation Coracle Marketing Soren chemical deals with water purification and swimming pool cleaning. Theyhave a new product Coracle that they have introduced to the market. Their initial product, Kailan MW performed so well, and they required something that was specific to small pools. It called for the introduction of Coracle washing chemical. However, they had a poor get-to-market strategy that dealt them a blow in terms of sales. Their distribution strategy was the business to business model. It meant that they had no direct access to the consumer. The main distribution channel partners were the wholesalers and retailers. The wholesalers would buy and sell to the retailers who had direct access to the consumer. However, a few chemical companies could sell directly to Wal-Mart, but it was expensive for small chemical companies. The packaging needs to be up to standard and have it as a product of its own. The marketing strategy should change and target the con sumer and not the wholesaler. Therefore, the distribution channel should change at least in the first few months. Getting directly to consumers will help in getting substantial feedback. We get from wholesalers and retailers may be altered to cater for their interests. As wholesalers care more about their margins, a direct consumer can advise on how the product should be adjusted to fit his or her needs. It would give a direct basis of the alteration of the products chemical composition to fit the customer need. It eases marketing costs. While launching a product, it is fundamental to reach the actual consumer since they offer information on how improvements should happen. The supplier scorecard is a powerful tool for customers to give feedback and make manufacturer improve over time (Hill, 2012).ReferenceHill, A. (2013). An Encyclopedia of Operations Management: A Field Manual and Glossary of Operations Management Terms, and Concepts. Upper Saddle River, N.J.: FTPress Delivers.

The psychological effects of people with intellectual disabilities Dissertation

The psychological effects of people with intellectual disabilities experiencing loss and bereavement - Dissertation Example This girl of 19 years and very dependent on her mother was not allowed to come anywhere near her mother’s body before she was taken away. She was being continually picked upon and that left her irritated and lost. The bereavement could not be handled by this girl and the attitude of her aunt made her worse. The community as a whole did not know how to handle grief associated with bereavement. The psychological responses such as yearning, anxiety, depression, distrust of others and complicated grief were expected of the intellectually disabled. Carers and staff were not prepared to recognise or to provide effective support at the time of loss and bereavement. Their ignorance of how to handle the situation could be the main culprit. Searching through the literature, I was surprised to find that little empirical research had been done to specifically look at the normal or complicated grief response in people with learning disabilities. On a personal level the subject is of great interest to me and it is intended that this research will increase my knowledge in theory and practice as well as enhancing the importance of research to my continuing professional development. History My search took me to the university Library. Electronic search engines and databases were looked through. PSYC INFO, CINAHL, PUBMED and the COCHRANE electronic databases helped me gather some material pertaining to the subject. The keywords used were bereavement, psychological reactions, loss, complicated grief, grief and learning disabilities. The Learning Resource Centre (LRC) library, Department of Health and Rowntree Foundation website helped me to retrieve grey literature. Boolean operators were used to narrow the results. Combined randomised controlled trials of bereaved adults with learning disabilities that compared community based interventions were included in the review. Life events with its psychological problems that were emotional, psychiatric and behavioural responses t o bereavement were also included. Recognition and concept of death by people with learning disabilities and their families and carers, as well as inclusion of assessment tools of complicated grief were selected. The exploration of support and interventions were also collected. A number of recent articles had considered the implications of grief and bereavement for people with learning disabilities. This had influenced me to concentrate on the parameters of the years between 2002 and 2010. Because of limited empirical studies I have included some of the articles with case studies illustrations. With eleven journal articles, I was ready to start on my hunt for ways of managing complicated grief in intellectually disabled persons. Could I be signalling off a process which has the outcome of the improved welfare and quality of life of the intellectually disabled at heart where bereavement grief is concerned? Critique of two articles on data collection and analysis Dodd, P., Guerin, S., McEvoy, J., Buckley, S., Tyrrell, J. & Hillery, J. (2008). A study of complicated grief symptoms in people with intellectual disabilities. Journal of Intellectual Disability Research, 52 (5), 415-425. The data were contained in the two assessment tools used for this study: Complicated Grief Questionnaire for People with Intellectual Disabilities (CGQ- ID) and Bereavement History Questionnaire (Adapted). The tools had been described

Assignment Example | Topics and Well Written Essays - 1000 words - 69

Assignment Example Fed can purchase government either securities or lowers current reserve rations. In doing so, interest rates will fall and hence bringing the economy back to full employment. Suppose on observing that there is excess money supply in the economy, Fed will use open market operations to try to reduce the excess supply. Sales of government securities contract the assets accessible to lend and tend to increase the federal funds rate. Policymakers call this contractionary monetary policy or tightening. The Fed is targeting an interest rate level that would enable it achieves and controls its goal for employment. Economic growth, interest rate stability, and inflation can hit this rate target by choosing an appropriate value of money supply that will equate to money for equilibrium conditions in the capital market. The sale of government securities leads to a decrease in money supply from MS1 to MS2 in the economy. As a result, the current reserve ratio increase and hence putting an upward pressure on the Fed interest rate (Setterfield 105-116). Therefore, contracting policy results in the increase in interest rates from R1 to R2 and hence the cost of borrowing from commercial banks increases discouraging borrowing. When Fed sells government securities, it reduces money supply in the economy. The fall in money supply results in an increase in interest rates to R2. The increase in the interest rates reduces the level of aggregate demand and investment to I2 and hence a reduction in real GDP. As soon as the economy is in the recessionary gap, the Fed will implement an expansionary monetary policy to upsurge money supply in the market through three monetary policy instruments. By buying government securities and bonds, the Fed target will be to reduce the interest rate level. Moreover, it can lower the reserve rate or lessen the discount rate. The move will lead to a reduction in lending rates; hence, commercial banks will be encouraged borrowing

According to Nietzsche, what did good and bad originally man in early Essay

According to Nietzsche, what did good and bad originally man in early heroic Western society Who (according to Nietzsche) re-valued this original meaning and changed it into good and evil What - Essay Example That is, ‘good’ was linked with the superior, privileged and noble, whereas ‘bad’ was linked with the common low and working-class (Guay, 96). Nevertheless, the offspring of the low class started resenting being inferior; they started resenting being ‘bad.’ Their hatred towards the upper-class led to a â€Å"radical changing of their ideals. Meaning ‘good’ and ‘bad’ started to reverse in meaning so that now ‘good’ defined the common, poor low, and inferior, whereas ‘bad’ now was for the powerful, rich, privileged and superior. In this manner, the deprived, sick, helpless and poor became virtuous, whereas the superior, noble and wealthy became wicked (Guay, 96). This transformation of values is likely when the hatred of the lesser classes for the powerful turns out to be so huge that they get reparation just in imagining or building a diverse moral system. It is this building of a contrasting moral system that is referred by Nietzsche as the slave morality. Thus, so that the powerless can have a better feeling of the circumstances that they are in, they build a morality for themselves, which is a slave morality, where the lesser are ‘good’ while the dominant are ‘evil.’ Nietzsche expresses his dissatisfaction with the psychologists who have attempted to give the origin of morality. They say that they are historians of morality; however they do not have a historical spirit. Their theories propose that originally individuals gain from altruism actions of others would applaud the actions and refer to them as ‘good.’ That means, what was initially ‘good’ and useful were taken as one and the same. With time, the genealogists propose, that the original association be forgotten, and the habit of referring to altruism actions ‘good’ resulted to the conclusion that they were somehow good of and in themselves (Guay, 97). Nietzsche does not agree with this account. He

Paul Hindemith Sonata For Flute And Piano Film Studies Essay

Paul Hindemith Sonata For Flute And Piano Film Studies Essay J.S.Bach: Sonata in G minor, for flute and obbligato harpsichord. In a famous remark about J.S.Bach, Beethoven said he should be named Sea instead of Bach, because of his infinite, inexhaustible wealth in tone combinations and harmonies. These virtues are also deployed in his flute sonatas, each with a unique melodic contour and character. Bach was often criticized for being abstruse and redundantly complex, but he was able to prove through his work that he was, and would remain, a great pioneer. The special importance of his chamber music, in which he demonstrated a deep knowledge of the typical idioms and performing techniques of each instrument, was recognized at a very early age. Bach is generally described as a rather austere personality, but that may be the result of a lack of information complementing his character, deemed unfitting for archival storage. The first use of the transverse flute in Bachs works was in Cantata no 137a, performed in 1722, in Cà ¶then for the birthday of Prince Leopold, with whom Bach maintained very good relations. Many significant works, such as the first book of the well-tempered Clavier, cello suites and probably some of the flute sonatas (they are dated between 1720 and 1741), were also composed during the time he spent there, exploiting the qualities and extended experience attained at the Weimar court. It was a period when the transverse flute, technically more advanced, began gaining ground against its rival, the recorder, and when J.Quantz started making it widely famous. The flutists of that era seemed to manifest a particular dexterity, equivalent to that, required not only in the flute sonatas, but also in other flute parts of many of the composers works, such as the cantatas and passions. In one of Bachs biographies, published in 1802, by Forkel, the latter states that the flute sonatas even in our days†¦would be heard by connoisseurs with pleasure. This particular work raises a controversial issue about its paternity. Bachs authority regarding the piece started to become questioned during the third decade of the 20th century. Scholars expressed certainty that Bachs son, Carl Phillip Emmanuel, is the composer of this sonata (the dominant consensus today), but until today, no assumption has been unquestionably proved and no explanation has been given as to why an aspiring composer like C.P.Emanuel would attribute this work to his father without any plausible reason. A recent study, by Keiichi Kubota, speculates that the g minor sonata is the result of a collaborative work between Bach and his son (the latter ascribing authority to his father). The sonata is played today by both violinists and flutists, as it is believed that the piece may have been written initially for violin, as supported in many published articles. Its form is that of the Italian concerto, lively-slow-lively, which reminds the listener of the significant influence of Vivaldi and Italian music to Bach. G.Faurà ©: Fantaisie pour flute et piano, op. 79 Flute has always been associated with France, a relation that is firmly built upon the particular interest of French composers and performers in this technically developed instrument, especially around the turn of the 19th century. Paris stood in the forefront of musical processes at the time, and served as an incubator for new composers and performers, who formed the new trends. Gabriel Faurà ©, a composer, organist, pianist, choirmaster and teacher, is one of the most important French figures of the turn of the 20th century, characterized by Debussy as the master of charms. He was fortunate enough to be a student and later friend of Saint-Saà «ns, at the Ecole Niedermeyer, where he was sent, after his father realized the unique talent of his son. His style, multi-faceted and resourceful, continued to evolve until the composers death, in 1924. For that reason, putting labels on Faurà ©s music can never be precise. His artistic hallmark is regarded as the bridge between Romanticism and Modernism and at the time of his death the second Viennese School was beginning to emerge. He was always self-critical (to the extent of discarding some of his already composed work) and pursued unremitting productiveness. His harmonic and melodic creativeness paved the road for new musical trends and made his style an inextricable element of future teaching of harmony and composition. Faurà © composed the Fantaisie for flute and piano, in 1898, upon a commission from his friend and colleague, P.Taffanel, who was a professor at the Conservatoire of Paris, and to whom the piece is dedicated (later Faurà © would be appointed director of the Conservatoire). This piece was to be used for the annual introductory exams (Concours). Faurà ©, being among the first composers to be commissioned for the morceau de concours, confessed to Saint-Saà «ns in a letter, that this piece constituted a real challenge for him. He sent it to Taffanel asking him to amend any parts that were not appropriate for the flute. Faurà © incorporated the Andante of the Fantaisie to his incidental music, performed in London for the Maeterlinks play, Pellà ©as et Mà ©lisande. This piece, which is dedicated to Taffanel, sets out to explore flutes full potential, by extending to all three registers, covering all of the Romantic instruments range. The performer is required to demonstrate wealth and diversity in his expression and sound, in his effort to trace the unfolding melody. Observation of the piano part reveals the prominence of the instrument in Faurà ©s mentality. It is perceived not merely as an accompanying instrument, but rather as an equal partner, contributing to the melodic and rhythmic development of the piece. Together with the flute they make use of an extensive expressional quiver, alternating staccatos with long legato phrases, as after a sicilienne-like introduction, an increasing complexity in the instruments parts is combined with sudden dynamic changes. Fantasia also exists in an orchestral version. This was realized later, after the composer death, by Louis Aubert, in 1957, at the request of the prominent French flutist, Jean Pierre Rampal. Paul Hindemith sonata for flute and piano (1936) In Hindemiths opera Mathis der Mahler, Grà ¼newald, a painter, realizes that he should never have betrayed his art for the sake of political activism. Hindemith though, never betrayed his versatile artistic personality and established a prominent career both as a performer and composer, demonstrating a manifold expressiveness. He aspired to create a new mentality in music, but not as an end in itself. The term Gebrauchsmusik (functional music) refers to his notion for music, which should be created to serve a purpose, because the days of composing only for the sake of composing were perhaps gone forever. By drawing on multiple styles and forms he explored all aspects of resourcefulness and complexity. His activity was not restricted only to the production of music, but he also took up a dynamic role as a tutor which is colligated with his series of simple works for children and amateurs. His theoretical treatise Unterweisung im Tonsatz, sets the basis for a new approach towards harmony and melodic shaping and the views expressed would influence the next generations of composers. Hindemith lived in an era of political turmoil and his revolutionary style could not have evaded Nazis attention, who deemed his music as Gà ¶bbels put it pure noise-making. Although Hindemith was naive enough to ignore (at the beginning at least) the Nazi threat, his sonata for flute and piano, composed in 1936, has incorporated this aspect, yielding a work that alludes to this sinister political environment and asserting the composers belief that an artist cannot remain untouched by the human suffering around him. The flute sonata was composed at a time of an increasing awareness by Hindemith of the looming danger and the subsequent need to flee his country. His emotional disposition is adumbrated in the second movement which conveys a suffering through its recitativo-like melody of the flute. One cannot fail to notice the fine irony emanating from the sonatas strict rhythmic form which dissolves into a childish-like melody, projecting the image of a child imitating a soldiers march. Hindemith, tried to capture the vanity of human arrogance in conjunction with the suffering and desperation. The flutist is required to render a wide palette of colors and emotions, from triumphant marches to bleak moments of agony and melancholy, by extending to the full range of the instrument. The piano has an emancipated part in the sonata and continuously moves in a contrapuntal way against the flute, hence sometimes its preferred with its lid open. The boundaries between minor and major chords and atonal parts become blurred, much as the boundaries between life and death at the time of the composition, the death which Hindemith eluded only by chance in multiple occasions.

Ecstasy, the Brain, and the Media :: Drugs Drug Chemistry Essays

Ecstasy, the Brain, and the Media Ecstasy has been glorified by countless Brit-pop drug anthems, condemned by staunch anti-drug foundations and even caused a controversial media debate when the post-mortem picture of eighteen year old Lorna Spinks was splashed across every newspaper in the United Kingdom, her Ecstasy-related death rendered in full gruesome color. The long-term effects and temporary consequences of Ecstasy have been a subject of heated debate in the past ten years as the pill has seen a surge in popularity. What exactly does Ecstasy do to the brain? What creates the euphoric effects? Why has it been used in therapy? And does the media's portrayal of Ecstasy rely on the facts of the drug, or skew the information to instill a sense of fear into citizens, parents, and teenagers? Ecstasy (Methlenedioxy-methamphetamine, MDMA for short) is a synthetic, psychoactive drug with amphetamine-like and hallucinogenic properties. It shares a chemical structure with methamphetamine, mescaline, and methylenedioxyamphetamine (MDA), drugs known to cause brain damage (1). MDMA, in a simple explanation, works by interfering with the communication system between neurotransmitters. Serotonin is one of a group of neurotransmitters that carries out communication between the body and the brain. The message molecules travel from neuron to neuron, attaching to receptor sites. This communication activates signs that either allow the message to be passed or prevent the message from being sent to other cells. However, when MDMA enters the nervous system, it interferes with this system. After serotonin is released, the neurotransmitters are retrieved into the nerve terminal where they are recycled. MDMA hinders this process so that the serotonin is not drawn back in. This allows for an accumulation of serotonin, and also an increase in serotonin synapses (2). This surge of serotonin creates an emotional openness in the Ecstasy user. A sense of euphoria and ecstatic delight envelop the user. Some users report thinking clearly and objectively, and often claim to come to terms with personal problems or various other skeletons in the closet (3). This is the reason Ecstasy resurfaced in the 1980s (after being developed in Germany in 1912 as a dieting drug due to the fact that amphetamines are appetite suppressors) as a tool in experimental psychotherapy, particularly regarding relationship and marital problems (4). In 1984 the drug was declared illegal in the United States after it started being used for recreational purposes. However, in June of 1999, Swiss courts ruled that dealing Ecstasy is not a serious offence.

Metabolism

Now that you are familiar with the structure of prokaryotic cells, we can discuss the activities that allow these microbes to thrive. The life support activity of even the most structurally simple organism involves a large number of complex biochemical reactions. Most, although not all, of the biochemical processes of bacteria also occur in eukaryotic microbes and in the cells of multicellular organisms, including humans. However, the reactions that are unique to bacteria are fascinating because they allow microorganisms to do things we cannot do (Neidhardt & Holde, 1990). For example, some bacteria (the chemoautotrophs) can grow on diets of such inorganic substances as carbon dioxide, iron, sulfur, hydrogen gas, and ammonia.This paper examines some representative chemical reactions that either produce energy (the catabolic reactions) or use energy (the anabolic reactions) in microorganisms. We will also look at how these various reactions are integrated within the cell.II. Discussio nA. Catabolic and Anabolic ReactionsWe use the term metabolism to refer to the sum of all chemical reactions within a living organism. Because chemical reactions either release or require energy, metabolism can be viewed as an energy-balancing act. Accordingly, metabolism can be divided into two classes of chemical reactions—those that release energy and those that require energy. In living cells, the chemical reactions that release energy are generally the ones involved in catabolism, the breakdown of complex organic compounds into simpler ones. These reactions are called catabolic, or degradative, reactions.On the other hand, the energy-requiring reactions are mostly involved in anabolism, the building of complex organic molecules from simpler ones. These reactions are called anabolic or biosynthetic reactions (Neidhardt & Holde, 1990). Anabolic processes often involve dehydration synthesis reactions (reactions that release water) and require energy to form a new chemical b onds.Examples of anabolic processes are the formation of proteins from amino acids, nucleic acids from nucleotides, and polysaccharides from simple sugars. These biosynthetic reactions generate the materials for cell growth. Catabolic reactions are generally hydrolytic reactions (reactions that use water to break chemical bonds). Chemical bonds store energy; when they are broken, chemical energy is released. An example of catabolism occurs when cells break down sugars into carbon dioxide and water.Catabolic reactions furnish the energy needed to drive anabolic reactions. This coupling of energy-requiring and energy-releasing reactions is made possible through the molecule adenosime triphospahte (ATP). ATP stores energy derived from catabolic reactions and releases it later to drive anabolic reactions and perform other cellular work. A molecule of ATP consists of an adenine, a ribose, and three phosphate groups.When the terminal phosphate group is split from ATP, adenosine diphosphat e (ADP) is formed, and energy is released to drive anabolic reactions. Using P to represent a phosphate group, we can write this reaction as (ATP—> ADP + P + energy). Then, the energy from catabolic reactions is used to combine ADP and a P to resynthesize ATP (ADP + P + energy—> ATP).Thus, anabolic reactions are coupled to ATP breakdown, and catabolic reactions are coupled to ATP synthesis. This concept of coupled reactions is very important. For now, you should know that the chemical composition of a living cell is constantly changing; some molecules are being broken down while others are being synthesized. This balanced flow of chemicals and energy maintains the life of a cell (â€Å"Metabolism; What is it exactly and how fast or slow should it be?†).B. EnzymesChemical reactions occur when chemical bonds are formed or broken. In order for reactions to take place, atoms, ions, or molecules must collide. Whether a collision produces a reaction depends on the spe ed of the particles, the amount of energy required to trigger the reaction (called activation energy), and the specific configuration of the particles. The physiological temperature and pressure of organisms are too low for chemical reactions to occur quickly enough to maintain the life of the organism.Raising the temperature and pressure and the number of reacting molecules can increase the frequency of collisions and the rate of chemical reactions. However, such changes could damage or kill the organism. The living cell’s solution to this problem is a class of proteins called enzymes. Enzymes can speed up chemical reactions in several ways. For example, an enzyme may bring two reactant molecules close together and may properly orient them to react. Whatever the method, the result is that the enzyme lowers the activation energy for the reaction without increasing the temperature or pressure inside the cell (â€Å"Immobilized Enzymes Can Check Bioterrorism, 2003).Substances that can speed up a chemical reaction without themselves being altered are called catalysts. In living cells, enzymes serve as biological catalysts. As catalysts, enzymes are specific. Each acts on specific substance, called the enzyme’s substrate (or substrates when there are two or more reactants), and each catalyzes only one reaction. For example, sucrose (table sugar) is the substrate of the enzyme sucrase, which catalyzes the hydrolysis of sucrose to glucose and fructose.The specificity of enzymes is made possible by their structures. Enzymes are generally globular proteins that range in molecular weight from about 10,000 to several million. Each of the thousands of known enzymes has a characteristics three-dimensional shape with a specific surface configuration as a result of its primary, secondary, and tertiary structures. The unique configuration of each enzyme enables it to â€Å"find† the correct substrate from among the large number of diverse molecules in t he cell (â€Å"Immobilized Enzymes Can Check Bioterrorism, 2003).C. Factors Influencing Enzymatic ActivitySeveral factors influence the activity of enzyme. Among the more important are temperature, pH, substrate concentration, and inhibitors.a.) TemperatureThe rate of most chemical reactions increases as the temperature increases. Molecules move more slowly at low than at higher temperatures and may not have enough energy to cause a chemical reaction. For enzymatic reactions, however, elevation beyond a certain temperature drastically reduces the rate of reaction. This decrease is due to the enzyme’s denaturation, the loss of its characteristics three-dimensional structure (tertiary configuration). Denaturation of a protein involves breakage of hydrogen bonds and other noncovalent bonds (Neidhardt & Holde, 1990).Most enzymes have a pH optimum at which their activity is characteristically maximal. Above or below this pH value, enzyme activity, and therefore the reaction rate, declines. When the H+ concentration (pH) in the medium is changed, many of the enzyme’s amino acids are affected and the protein’s three-dimensional structure is altered. Extreme changes in pH can cause denaturation (Neidhardt & Holde, 1990).Substrate ConcentrationThere is a maximum rate at which a certain amount of enzymes can catalyze a specific reaction. Only when the concentration of substrate(s) is extremely high can this maximum rate be attained. Under conditions of high substrate concentration, the enzyme is said to be saturated; that is, its active site is always occupied by substrate or product molecules. In this condition, a further increase in substrate concentration will not affect the reaction rate because all active sites are already in used. If a substrate’s concentration exceeds a cell’s saturation level for a particular enzyme, the rate of reaction can be increased only if the cell produces additional enzyme molecules (Neidhardt & Holde, 1990). However, under normal cellular conditions, enzymes are not saturated with substrate (s). At any given time, many of the enzyme molecules are inactive for lack of substrate; thus, the rate of reaction is likely to be influenced by the substrate concentration.InhibitorsAn effective way to control the growth of bacteria is to control their enzymes. Certain poisons, such as cyanide, arsenic, and mercury, combine with enzymes and prevent them from functioning. As a result, the cells stop functioning and die.Enzyme inhibitors are classified according to their mechanism of action as competitive inhibitors and noncompetitive inhibitors. Competitive inhibitors fill the active site of an enzyme and compete with the normal substrate for the active site. The competitive inhibitor is able to do this because its shape and chemical structure are similar to those of the normal substrate.Noncompetitive inhibitors do not compete with the substrate for the enzyme’s active site; instead they interact with another part of the enzyme. In this process, called allosteric (â€Å"other space†) inhibition, an enzyme’s activity is reduced because of a change in shape caused by binding of an inhibitor at a site rather than substrate’s binding site. The change in shape can be either reversible or irreversible (Neidhardt & Holde, 1990).III. ConclusionIn conclusion, the sum of all chemical within a living organism is known as metabolism. Catabolism refers to chemical reactions that result in the breakdown of more complex organic molecules into simpler substances. Catabolic reactions usually release energy. Anabolism refers to chemical reactions in which simpler substances are combined to form more complex molecules. Anabolic reactions usually require energy. The energy of catabolic reaction is used to drive anabolic reactions. The energy for chemical reactions is stores in ATP. Moreover, the enzymes are proteins produced by living cells that catalyze chemi cal reactions. They are generally globular proteins with characteristic three-dimensional shapes.Reference:Neidhardt, F.C. and K.E. van Holde. Biochemistry. Redwood City, Calif: Benjamin/Cummings, 1990. A biochemistry test with chapters on metabolic pathways of energy production and biosynthesis. â€Å"Metabolism; What Is It Exactly and How Fast or Slow Should It Be?† The Washington Times, January 31, 2006. â€Å"Immobilized Enzymes Can Check Bioterrorism.† USA Today (Society for the Advancement of Education), Vol. 131, June 2003 Metabolism The life support activity of even the most structurally simple organism involves a large number of complex biochemical reactions. Most, although not all, of the biochemical processes of bacteria also occur in eukaryotic microbes and in the cells of multicellular organisms, including humans. However, the reactions that are unique to bacteria are fascinating because they allow microorganisms to do things we cannot do (Neidhardt & Holde, 1990). For example, some bacteria (the chemoautotrophs) can grow on diets of such inorganic substances as carbon dioxide, iron, sulfur, hydrogen gas, and ammonia.This paper examines some representative chemical reactions that either produce energy (the catabolic reactions) or use energy (the anabolic reactions) in microorganisms. We will also look at how these various reactions are integrated within the cell.II. DiscussionA. Catabolic and Anabolic ReactionsWe use the term metabolism to refer to the sum of all chemical reactions within a living organism. Because chemical reactions either release or require energy, metabolism can be viewed as an energy-balancing act. Accordingly, metabolism can be divided into two classes of chemical reactions—those that release energy and those that require energy. In living cells, the chemical reactions that release energy are generally the ones involved in catabolism, the breakdown of complex organic compounds into simpler ones.These reactions are called catabolic, or degradative, reactions. On the other hand, the energy-requiring reactions are mostly involved in anabolism, the building of complex organic molecules from simpler ones. These reactions are called anabolic or biosynthetic reactions (Neidhardt & Holde, 1990). Anabolic processes often involve dehydration synthesis reactions (reactions that release water) and require energy to form a new chemical bonds.Examples of anabolic processes are the formation of proteins from amino acids, nucleic acids from nucleotides, and polysaccharide s from simple sugars. These biosynthetic reactions generate the materials for cell growth. Catabolic reactions are generally hydrolytic reactions (reactions that use water to break chemical bonds). Chemical bonds store energy; when they are broken, chemical energy is released. An example of catabolism occurs when cells break down sugars into carbon dioxide and water.Catabolic reactions furnish the energy needed to drive anabolic reactions. This coupling of energy-requiring and energy-releasing reactions is made possible through the molecule adenosime triphospahte (ATP). ATP stores energy derived from catabolic reactions and releases it later to drive anabolic reactions and perform other cellular work. A molecule of ATP consists of an adenine, a ribose, and three phosphate groups. When the terminal phosphate group is split from ATP, adenosine diphosphate (ADP) is formed, and energy is released to drive anabolic reactions.Using P to represent a phosphate group, we can write this react ion as (ATP—> ADP + P + energy). Then, the energy from catabolic reactions is used to combine ADP and a P to resynthesize ATP (ADP + P + energy—> ATP). Thus, anabolic reactions are coupled to ATP breakdown, and catabolic reactions are coupled to ATP synthesis. This concept of coupled reactions is very important. For now, you should know that the chemical composition of a living cell is constantly changing; some molecules are being broken down while others are being synthesized. This balanced flow of chemicals and energy maintains the life of a cell (â€Å"Metabolism; What is it exactly and how fast or slow should it be?†).B. EnzymesChemical reactions occur when chemical bonds are formed or broken. In order for reactions to take place, atoms, ions, or molecules must collide. Whether a collision produces a reaction depends on the speed of the particles, the amount of energy required to trigger the reaction (called activation energy), and the specific configuration of the particles. The physiological temperature and pressure of organisms are too low for chemical reactions to occur quickly enough to maintain the life of the organism. Raising the temperature and pressure and the number of reacting molecules can increase the frequency of collisions and the rate of chemical reactions. However, such changes could damage or kill the organism.The living cell’s solution to this problem is a class of proteins called enzymes. Enzymes can speed up chemical reactions in several ways. For example, an enzyme may bring two reactant molecules close together and may properly orient them to react. Whatever the method, the result is that the enzyme lowers the activation energy for the reaction without increasing the temperature or pressure inside the cell (â€Å"Immobilized Enzymes Can Check Bioterrorism, 2003).Substances that can speed up a chemical reaction without themselves being altered are called catalysts. In living cells, enzymes serve as biolog ical catalysts. As catalysts, enzymes are specific. Each acts on specific substance, called the enzyme’s substrate (or substrates when there are two or more reactants), and each catalyzes only one reaction. For example, sucrose (table sugar) is the substrate of the enzyme sucrase, which catalyzes the hydrolysis of sucrose to glucose and fructose.The specificity of enzymes is made possible by their structures. Enzymes are generally globular proteins that range in molecular weight from about 10,000 to several million. Each of the thousands of known enzymes has a characteristics three-dimensional shape with a specific surface configuration as a result of its primary, secondary, and tertiary structures. The unique configuration of each enzyme enables it to â€Å"find† the correct substrate from among the large number of diverse molecules in the cell (â€Å"Immobilized Enzymes Can Check Bioterrorism, 2003).C. Factors Influencing Enzymatic ActivitySeveral factors influence the activity of enzyme. Among the more important are temperature, pH, substrate concentration, and inhibitors.  a.) TemperatureThe rate of most chemical reactions increases as the temperature increases. Molecules move more slowly at low than at higher temperatures and may not have enough energy to cause a chemical reaction. For enzymatic reactions, however, elevation beyond a certain temperature drastically reduces the rate of reaction. This decrease is due to the enzyme’s denaturation, the loss of its characteristics three-dimensional structure (tertiary configuration). Denaturation of a protein involves breakage of hydrogen bonds and other noncovalent bonds (Neidhardt & Holde, 1990).b.) pHMost enzymes have a pH optimum at which their activity is characteristically maximal. Above or below this pH value, enzyme activity, and therefore the reaction rate, declines. When the H+ concentration (pH) in the medium is changed, many of the enzyme’s amino acids are affected an d the protein’s three-dimensional structure is altered. Extreme changes in pH can cause denaturation (Neidhardt & Holde, 1990).c.) Substrate ConcentrationThere is a maximum rate at which a certain amount of enzymes can catalyze a specific reaction. Only when the concentration of substrate(s) is extremely high can this maximum rate be attained. Under conditions of high substrate concentration, the enzyme is said to be saturated; that is, its active site is always occupied by substrate or product molecules. In this condition, a further increase in substrate concentration will not affect the reaction rate because all active sites are already in used. If a substrate’s concentration exceeds a cell’s saturation level for a particular enzyme, the rate of reaction can be increased only if the cell produces additional enzyme molecules (Neidhardt & Holde, 1990). However, under normal cellular conditions, enzymes are not saturated with substrate (s). At any given time, man y of the enzyme molecules are inactive for lack of substrate; thus, the rate of reaction is likely to be influenced by the substrate concentration.d.) InhibitorsAn effective way to control the growth of bacteria is to control their enzymes. Certain poisons, such as cyanide, arsenic, and mercury, combine with enzymes and prevent them from functioning. As a result, the cells stop functioning and die.Enzyme inhibitors are classified according to their mechanism of action as competitive inhibitors and noncompetitive inhibitors. Competitive inhibitors fill the active site of an enzyme and compete with the normal substrate for the active site. The competitive inhibitor is able to do this because its shape and chemical structure are similar to those of the normal substrate.Noncompetitive inhibitors do not compete with the substrate for the enzyme’s active site; instead they interact with another part of the enzyme. In this process, called allosteric (â€Å"other space†) inhib ition, an enzyme’s activity is reduced because of a change in shape caused by binding of an inhibitor at a site rather than substrate’s binding site. The change in shape can be either reversible or irreversible (Neidhardt & Holde, 1990).III. ConclusionIn conclusion, the sum of all chemical within a living organism is known as metabolism. Catabolism refers to chemical reactions that result in the breakdown of more complex organic molecules into simpler substances. Catabolic reactions usually release energy. Anabolism refers to chemical reactions in which simpler substances are combined to form more complex molecules. Anabolic reactions usually require energy. The energy of catabolic reaction is used to drive anabolic reactions. The energy for chemical reactions is stores in ATP. Moreover, the enzymes are proteins produced by living cells that catalyze chemical reactions. They are generally globular proteins with characteristic three-dimensional shapes.Reference:Neidhard t, F.C. and K.E. van Holde. Biochemistry. Redwood City, Calif: Benjamin/Cummings, 1990. A biochemistry test with chapters on metabolic pathways of energy production and biosynthesis. â€Å"Metabolism; What Is It Exactly and How Fast or Slow Should It Be?† The Washington Times, January 31, 2006. â€Å"Immobilized Enzymes Can Check Bioterrorism.† USA Today (Society for the Advancement of Education), Vol. 131, June 2003

Malaysian Culture Essay

Malaysia has a multi-ethnic, multicultural, and multilingual society. The original culture of the area stemmed from indigenous tribes that inhabited it, along with the Malays who later moved there. Substantial influence exists from Chinese and Indian culture, dating back to when foreign trade began. Other cultural influences include the Persian, Arabic, and British cultures. Due to the structure of the government, coupled with the social contract theory, there has been minimal cultural assimilation of ethnic minorities. Traditional Malaysian art was mainly centred around the areas of carving, weaving, and silversmithing.[181] Traditional art ranges from hand-woven baskets from rural areas to the silverwork of the Malay courts. Common artworks included ornamental kris, beetle nut sets, and woven batik and songket fabrics. Indigenous East Malaysians are known for their wooden masks.[94] Each ethnic group have distinct performing arts, with little overlap between them. However, Malay art does show some North Indian influence due to the historical influence of India. Traditional Malay music and performing arts appear to have originated in the Kelantan-Pattani region with influences from India, China, Thailand and Indonesia. The music is based around percussion instruments, the most important of which is the gendang (drum). There are at least 14 types of traditional drums. Drums and other traditional percussion instruments and are often made from natural materials. Music is traditionally used for storytelling, celebrating life-cycle events, and occasions such as a harvest. It was once used as a form of long-distance communication.[183] In East Malaysia, gong-based musical ensembles such as agung and kulintang are commonly used in ceremonies such as funerals and weddings. These ensembles are also common in neighbouring regions such as in the southern Philippines, Kalimantan in Indonesia, and Brunei. Malaysia’s cuisine reflects the multi-ethnic makeup of its population.[186] Many cultures from within the country and from surrounding regions have greatly influenced the cuisine. Much of the influence comes from the Malay, Chinese, Indian, Thai, Javanese, and Sumatran cultures,[94] largely due to the country being part of the ancient spice route.[187] The cuisine is very similar to that of Singapore and Brunei,[107] and also bears resemblance to Filipino cuisine.[94] The different states have varied dishes,[107] and often the food in Malaysia is different from the original dishes.[142]

Physiology labs essays

Physiology labs essays Properties of the Isolated Mammalian If we were to compare smooth muscle with skeletal muscle we notice that they are very different from one another. Firstly, smooth muscles have a slow cycling of myosin cross bridges as compared to skeletal muscle. However, the fraction of time that the cross bridges remain attached to the actin filaments is believed to be greatly increased in smooth muscle. Secondly, Less energy is required to sustain the same tension of contraction in smooth muscle as in skeletal muscle. Thirdly, The maximum force of contraction of smooth muscle is often even greater than that of skeletal muscle. This great force of smooth muscle contraction results from the prolonged period of attachment of the myosin cross-bridges to the actin filaments. The Gastrointestinal tract has 2 major networks of nerve fibers - Myenteric plexus and the Submucous plexus. The plexuses are interconnected, and they contain motor neurons that innervate the smooth muscle. This is the enteric nervous system. The intestine also receives a dual extrinsic innervation from the autonomic nervous system, with parasympathetic cholinergic activity generally increasing the activity of intestinal smooth muscle and the sympathetic noradrenergic activity generally decreasing it while causing the sphincters to contract. The GI tract is made up of smooth muscles. The individual smooth muscle fibers are between 200 and 500 micrometers in length and 2 and 10 micrometers in diameter, and they are arranged in bundles of as many as 1000 parallel fibers. In general, smooth muscle can be divided into Visceral smooth muscle and Multi-unit smooth muscle. Visceral smooth muscle occurs in large bundles. Within each bundle, the muscle fibers are electrically connected with one another through large numbers of gap junctions that allow low-resistance movement of ions from one cell to the next. Each layer functions as a syncytium; that is, when an action potenti...

Constitutional Law and The Criminal Justice System Coursework

Constitutional Law and The Criminal Justice System - Coursework Example This is more in presenting or challenging the evidences within a meaningful manner. Furthermore, the lawyer helps in maintaining the proper conduct of the defense, in addition to guiding their clients all through the trial in such a manner that the defense is displayed with its complete force plus effect (Harr, Hess, & Orthman, 2012 372). Both sides need to know how to establish their position that is why the presence of the lawyer is significant. Furthermore, given that the responsibility of the lawyer is to take steps for the benefit of another person is a fiduciary relationship, then the presence of the lawyer makes the trial to be fair as it generates particular legal obligations as well as responsibilities (Harr, Hess, & Orthman, 2012 374). Why People Prefer Pro Se Representation People would want to represent themselves in court pro se, mainly for the reason that they have a distrust for lawyers in general. Others believe that they can personally deal with their defense effecti vely, and others will seek to represent themselves owing to their lack of qualification for legal aid and hiring a private lawyer turns out to be expensive (Harr, Hess, & Orthman, 2012 387). ... with complexities, there should be a right to self-representation but this should only be based on the intricacy of the case as well as the formality of the debate (Harr, Hess, & Orthman, 2012 390). Notably, when individuals represent themselves they are accorded the possibility to truly articulate what they feel instead of having their insight filtered through the lawyer. However, when it comes to criminal trials, self representation should not be in place due to the complex nature of the trial process. In complicated trials it is difficult even for the most intelligent and educated citizen to learn the complex aspects of the law, and as a result precise court procedure can be complicated and stressful. Thus, the objective for a lawyer in complicated cases rather than self representation is to safeguard the integrity of the procedure and to guarantee a fair trial (Harr & Hess, 2007 388). Trial by Media Limitation Even though, a public trial advances the fundamental fairness of the t rial as well as the position of fairness when it comes to enhancing public confidence, there has to be a balance between the sixth amendment right of the defendant on one hand and the general public first amendment rights on the other hand (Harr, Hess, & Orthman, 2012 366). Hence, the media is not allowed to attend every trial unless there is a compelling reason in doing otherwise, in particular the safety. The other boundary is when the coverage by the media can cause a worry that the accused will be in danger due to disruption within the court, or the trial becomes somewhat of a three ring spectacle which in the end wipes out the dignified atmosphere as required in court proceedings (Harr, Hess, & Orthman, 2012 366). Barring the Media from Attending Trials This issue of the defendants

Research Proposal Essay Example | Topics and Well Written Essays - 2250 words - 3

Research Proposal - Essay Example Along with the business enterprises, the term has also gained its applicability in social service oriented institutions such as schools, nursing-homes and hospitals. Hence, it is largely differentiated from the other business and social service oriented activities (Dagoon, 2005). With the gradual change in the business scenario, it is quite certain that the global outlook has also changed in terms of Entrepreneurship. Presently, the entrepreneurs have innumerable opportunities rewarded by the economy such as technology, flexible policies for global trade, and increasing demand. But there are also few major challenges that entrepreneurs need to face while creating a new business idea and serve it to the ultimate customers. Few of them are high level of competition, constantly increasing demand for innovations, rigidity of government norms like taxation and others. Moreover, as it depends highly on the issue of personal perceptions and the environmental influences of the entrepreneurs, the applicability of entrepreneurship also differs from one economy to other and from one business to another (Viramgami, 2007). Hence, this paper shall concentrate on the aim to understand the modern day phenomenon of entrepreneurship in two different countries, India and the United Kingdom. As these economies are largely different in terms of both social and economic attributes it shall be beneficial to critically analyse the entrepreneurial process. Moreover, the proposed paper shall centre on the business sector comprising of entrepreneurial process related to the petrol station-cum- convenience store. The paper shall try to conclude on the aspect of development of entrepreneurship in both these economies with the help of wide ranging researches. With a growing emphasis on the term ‘Entrepreneurship’, several theorists and analysts have stated their viewpoint in various literatures and research papers. These are beneficial to critically evaluate the meaning of the term. In

A journal article critique in the family health area - 1

A journal critique in the family health area - Article Example The author employed the methods correctly since all the results indicated that chiropractic care produced positive results that improved the quality of life. However, there might be error in the research, since the author assumes that those who do not get chiropractic care do not get other health services, but in reality they could be receiving other health care in different forms. The evidence in support of the topic can be the 1992 research where people who received chiropractic care had a higher immunity than the average population or cancer patients. Dr. Petro states that chiropractic health care imparts maximum efficiency to whatever genetic makeup one may be possessing, while in the 2005 research, the study indicates that chiropractic health care determines normal physiological process which influence DNA repair and oxidative stress. This implies that subluxations removal has a positive influence on health. The strength of the evidence can be that chiropractic care has positive results on the immune system and can be recommended for quality life, while the weakness can be that those who got chiropractic care may have lived in the same environment which favored the practice or have specific biological background. The author supported the topic by explaining that the immune and nervous system were connected, and therefore manipulating the nervous system would produce a result, which in this case is chiropractic care which has positive results on the immune system. Other authors have conducted chiropractic research. They include shekelle et al (1992) and they concluded that manipulation of the spine fastens recovery from minor low back pains, after literature review on 25 trials. Van Tudler, Bouter and Koes in Netherlands found superior evidence for efficiency of manipulating the spine for chronic back pain. Bronfort (1999) conducted a review and found short term capacity

Personal Finance Essay Example for Free

Personal Finance Essay Personal finance addresses the way an individual or families earn, budget, save, and spend money gained from employment, loans, or gifts. As a college student, my personal finances are based upon money I have obtained, seasonal employment and parental support. In creating my budget, I had to realize that my income was not the same each month so I had to make sure I had enough money to pay for my gas, phone bill, and entertainment. Sometimes I would go over budget due to unexpected bills so I would ask for help from my parents. I use a debit card through my bank City National Bank. I chose this bank because my parents also bank there and it’s a small personal bank. It makes it easier if I need my mom to transfer money to my account in case of an emergency. I do not use checks only my debit card and occasional cash, the debit card pulls money out of my account somewhat like a check. I do check my account online, and my statement looks similar to the on in The Money 101 Student Workbook. The format is a little different, but the same kind of information is given. I do not keep a register much to my mother’s dismay. Every Christmas, she gives me a register to keep track of my spending but I fail to use it. I do track my spending through balance inquiries that I receive via the ATM, as well as online. If I wanted to change banks, I would choose a bank that would be in Marshall and has the small town feel to it. I would also want one that might offer interest on my account. I didn’t find any new information concerning debit cards, but I do prefer a debit card to a credit card because it takes money out of your account instead of possibly spending what you don’t have. You can also abuse a credit card and use it unnecessarily. I did check on annualcreditreport. com to see if I had a credit report, but I do not because I don’t have any accounts in my name. The best card deal I found was on chase. com because if I put my name on my parents account then I could also have their 8. 99% interest rate. There were lots of credit card offers that had 0% introductory rates, but since I have no credit, then the interest rate would rise dramatically. Some insurance policies that would be important for personal finance would be disability insurance, car insurance, and health insurance. Identity theft insurance would probably be a good insurance protection. The thing that stuck out to me when Mike Brady came and spoke was the concept of â€Å"full coverage† insurance for your car, he said that it’s only an interpretation and not something that is written down, he also stated that there is no such thing as â€Å"full coverage. I would probably put my savings in the savings account in my bank since I would have access to it. My retirement plan would be to match whatever my company is putting into my 401K and putting money into stock that I can draw from when I actually do retire. The test that we took in the back of the booklet was fairly easy after looking through this so many times I answered a credit card would be the one to hurt you the most when in fact it says the student loans would affect your credit score more. My parents educated me very well on a lot of these subjects especially budget and checking account, my mom has preached to me about having a budget for as long as I can remember. The thing I learned from this unit, just to point one out, was the savings and retirement planning I didn’t realize it was such a priority because at my age you really don’t think about those things but I’ve learned that I do need to start early.

Causes of Chronic Migraines

Causes of Chronic Migraines Headache is pain in any part of the head that can occur suddenly or gradually and produce a varying amount of pain; in fact, it is the most common form of pain in the United States (U.S. Department of Health and Human Services, 2014). Headache is often divided into two categories, primary and secondary (U.S. Department of Health and Human Services, 2014). A primary headache is one that is due to the headache itself, it is not caused by another problem (U.S. Department of Health and Human Services, 2014). The three types of primary headache include tension headaches, cluster headaches, and migraine headaches (U.S. Department of Health and Human Services, 2014). Secondary headaches, on the other hand, are headaches that are caused by something else (U.S. Department of Health and Human Services, 2014). Examples of secondary headaches include headaches from an illness, headaches from a medication, sinus headaches, cervicogenic headaches (which are headaches related to an underlying neck condition, like degenerative disc disease), and headache due to a brain tumor or aneurysm (U.S. Department of Health and Human Services, 2014). Migraine headaches are one of the most common forms of headache (Davanzo, Bua, Paloni, Facchina, 2014). Migraines are considered a neurological condition (Schwedt, 2014; Silberstein, 2014). They often manifest as recurrent attacks of throbbing, frequently unilateral headaches with associated features, including: nausea, vomiting, photophobia, and phonophobia (Pietrobon Moskowitz, 2012; Schwedt, 2014). Migraines can be further subdivided into episodic or chronic (Schwedt, 2014). Episodic migraine sufferers have less than 15 headache days a month, whereas chronic sufferers have at least 15 headache days a month for at least three months, and at least eight headaches that have symptoms consistent with a full-blown migraine attack (Ferrari, 2013; Schwedt, 2014). Chronic migraine is a common disorder; it impacts people during their most productive years of life, has tremendous costs to the individual and society, and is associated with a variety of comorbid disorders (Schwedt, 2014). Chronic migraine typically develop through a process called migraine transformation, which is a slow increase in the frequency of headaches, usually over a period of months to years (Schwedt, 2014). Chronic migraine is diagnosed based on the patient’s symptoms by excluding other causes of headache (Schwedt, 2014). A general physical and neurological exam should be performed on each patient and attention should be paid to the patient’s neck, shoulders, temporal artery pulses, and tempromandibular joint; if any abnormalities are found on the neurological exam, a secondary headache should be suspected and the patient should undergo further evaluation (Schwedt, 2014). Many risk factors are associated with a higher likelihood of transformation from episo dic to chronic migraine and include obesity, excessive caffeine intake, low socioeconomic status, and major life changes like marriage or divorce, to name a few (Schwedt, 2014). Common conditions comorbid with chronic migraine include other neurological disorders, gastrointestinal problems, and cerebrovascular disease (Pietrobon Moskowitz, 2012; Schwedt, 2014). Compared to people with episodic migraines, patients with chronic migraine are twice as likely to have certain psychiatric disorders, including anxiety, depression, and bipolar disorder (Schwedt, 2014). The pathophysiology of chronic migraine is complicated and not fully understood (Schwedt, 2014). It was once believed that migraines were simply a swelling of the blood vessels in the brain (Pietrobon Moskowitz, 2012). More recent experiments have shown that swelling of the meninges and/or extracranial arteries is neither necessary nor sufficient to cause migraine pain (Pietrobon Moskowitz, 2012). While such swelling is certainly often found during migraines, migraines are no longer assumed to be exclusively a disorder of blood vessels; rather, there are data to suggest that chronic migraine is associated with progressive brain changes, both in brain structure and brain function (Ferrari, 2013; Pietrobon Moskowitz, 2012). Atypical modulation of pain is suspected to play a role in the transformation from episodic to chronic migraine by reducing the inhibition of pain in the regions of the descending pain modulatory pathway in the brain (Schwedt, 2014). Neuroimaging studies of patie nts with chronic migraine have shown both atypical structures of pain processing and atypical pain processing in the brain (Schwedt, 2014). Regions of the brain that participate in sensory discrimination, affect, and the cognitive appraisal of pain are also atypical in migraine sufferers (Schwedt, 2014; Silberstein, 2014). Many studies have found correlations among the extent of these abnormalities and the frequency and severity of migraine headaches, suggesting that these abnormalities could be precursor to the transformation from episodic to chronic migraine (Schwedt, 2014), but more research is necessary to determine the exact role and mechanism of these abnormalities. The trigemininovasular system is currently considered one of the major players in the role of chornic migraine (Pietrobon Moskowitz, 2012; Schwedt, 2014). The trigeminal nerve is the fifth cranial nerve in the body and is the main sensory nerve in the head (Fix Brueckner, 2009). Some researchers believe that the musculature around the trigeminal nerve branches become irritated, which leads to the swelling and pain caused by migraine headaches (Kurlander, Punjabi, Liu, Sattar, Guyuon, 2013). Presently it is speculated that a sensitization of the trigeminal system that innervates cranial tissues, specifically the meninges (which often swell during migraine attacks) leads to a lower threshold for activation (Pietrobon Moskowitz, 2012; Schwedt, 2014). A lower threshold for activation means the system becomes activated more easily, which leads to more migraine attacks, and more migraine attacks therefore increase the likelihood of a chronic migraine diagnosis (Pietrobon Moskowitz, 20 12; Schwedt, 2014). Another line of research that is currently being investigated is cortical hyperexcitability (Schwedt, 2014). The human nervous system is composed of billions of synapses and neurons functioning as part of a large, highly specializes system (Fix Brueckner, 2009). All aspects of behavior are informed by the nervous system, and it can rudimentarily be broken down into excitatory and inhibitory components that facilitate the communication among different neurotransmitters in the brain to determine the level of inhibition of excitation of each response (Fix Brueckner, 2009). Excitation in the brain is mainly associated with the neurotransmitter glutamate (Fix Brueckner, 2009). Recent transcranial magnetic stimulation studies on patients with chronic migraine have shown cortical hyperexcitability, particularly in the occipital cortex of the brain. The occipital cortex is associated with vision, and this makes sense to researchers as visual auras are often associated with migraine attack s (Fix Brueckner, 2009; Schwedt, 2014). A neurotransmitter of interest, particularly with the beginning phase of a migraine attack, is dopamine (Charles, 2012). Some research has shown that dopamine receptor agonists administered to patients produce some of the same symptoms that are experienced by migraine sufferers at the beginning of an attack (Charles, 2012). Conversely, dopamine receptor antagonists administered to patients can reverse those symptoms and have even been suggested to have the ability to prevent the onset of additional migraine attacks (Charles, 2012). While the exact role of dopamine in chronic migraine is unknown, it is certainly an interesting line of future study. Treatments for chronic migraine range from trigger identification and avoidance to risk-factor modification, and include both pharmacological and nonpharmacological components (Schwedt, 2014). A discussion of each type of treatment and the variety of treatments within is beyond the scope of this review, however, some of the most common pharmacological treatments will be highlighted. Pharmacological treatment for migraines can be divided into two categories: abortive drugs, which stop a headache after onset, and prophylactic drugs, which are taken on a regular basis to prevent the onset of a migraine (Davanzo et al., 2014). Those who suffer from chronic migraine are often on a prophylactic regimen, due to the intensity and severity of the headaches (Davanzo et al., 2014). While many drugs are used for chronic migraine prophylaxis, it is important to note that many are prescribed off label; in fact, the only drug approved by the Food and Drug Administration for the treatment of chronic migraine is onabotulinumtoxinA (Schwedt, 2014). OnabotulinumtoxinA, more commonly known as Botox, has been popularized as a series of small injections in the face that reduce the appearance of crow’s feet and frown lines (Oliver, MacDonald, Rajwani, 2006). However, the injections are also used to treat chronic migraine (Schwedt, 2014). Botox is part of a class of medications called neurotoxins (Fix Brueckner, 2009). It has no direct effect on the central nervous system because it cannot penetrate the blood brain barrier, however, it can have some important indirect effects on the central nervous system (Fix Brueckner, 2009; Oliver, MacDonald, Rajwani, 2006). When used to treat chronic migraine, Botox is injected into different muscles in the face to block the nerve signals to those muscles (Fix Brueckner, 2009; Oliver, MacDonald, Rajwani, 2006). Specifically, Botox has been shown to inhibit sensitizations of central trigeminal nerves, which was previously discussed regarding the pathophysiology of chronic migraine (Ol iver, MacDonald, Rajwani, 2006). Triptans are another common class of drugs used for chronic migraine prophylaxis (Davanzo et al., 2014). Triptans are serotonin receptor agonists, meaning they bind to serotonin and increase the response of serotonin at the site of action (Davanzo et al., 2014; Fix Brueckner, 2009). Triptans have a vasoconstriction action on blood vessels, meaning they shrink the size of blood vessels, which is helpful in reducing the pain of migraines some of which can be attributed to swollen blood vessels in the brain (Davanzo et al., 2014). However, the desired effect of vasoconstriction is not limited to just the brain and also constricts other blood vessels, including those in the heart (Davanzo et al., 2014). As a result, patients with any coronary disease should use care when taking triptans (Davanzo et al., 2014). The most commonly prescribed triptan medication is Sumatriptan and is available in multiple forms including pills, injections, and intranasal spray (Davanzo et al., 2014). The inj ections and intranasal spray reach the brain more quickly and are therefore faster acting than the pill which must first get absorbed into the blood stream to take effect (Davanzo et al., 2014). Beta blockers, originally used for the treatment of hypertension and angina, are also often used for migraine prophylaxis (Davanzo et al., 2014). The beta part of beta blockers refers to receptors on blood vessels that are called beta receptors (Fix Brueckner, 2009). Therefore, beta blockers prevent the interaction of certain chemicals with this receptor (Fix Brueckner, 2009). The most commonly prescribed beta blocker for chronic migraine is Propranolol (Davanzo et al., 2014). Propranolol is likely successful in preventing migraine headaches by blocking beta adrenergic receptors, which inhibits swelling of arteries. Additionally, Propranolol may also exhibit its effect by preventing the platelets (the sticky elements of the blood) from sticking together and releasing substances that caused the blood vessels to constrict and dilate. A concern with pharmacological treatment of chronic migraine is the development of medication overuse headaches. These occur when a migraine sufferer uses migraine drugs too frequently, and develops a secondary headache as a result of the medication use (Schwedt, 2014). The treatment includes a drug withdrawal phase, during which time the patient would have to stop taking medication for his migraine or take a medication with different mechanism of action to allow the overused drug to leave his system (Schwedt, 2014). This response is paradoxical because sufferers of chronic migraine often rely on pharmacological treatments to alleviate their pain, but if they take too much they will actually end up exacerbating their pain. About half of chronic migraine sufferers are treated for medication overuse headaches at some point (Schwedt, 2014). A brief overview of the criteria for diagnosis, hypothesized pathophysiology, and pharmacology for the treatment of chronic migraine has been discussed. While there is still much to learn about the pathophysiology of chronic migraine, recent research has increased the understanding and opened up new areas of research to bring scientists closer to a more comprehensive understanding. While many data indicate that chronic migraine is a debilitating condition with great intensity and duration of headaches, and often lead to lost productivity and high costs on society (Schwedt, 2014), there are prophylactic and abortive drugs that can greatly ameliorate the problems caused by migraines. With attention to and modification of risk factors, often in addition to appropriate adherence to these medications, migraine sufferers can live normal, productive lives.

Ethical Dilemma Essays -- Health Care, Nurses

The two principles that are in focus are beneficence and nonmaleficence. Both beneficence and nonmaleficence have played a fundamental historical role in medical ethics (Beauchamp & Childress, 2009). Nonmaleficence is often paired with beneficence, but there is a difference between these two principles (Rich, 2008). According to Beauchamp and Childress (2009) conflating beneficence and nonmaleficence into a single principle obscures important distinctions. In addition, both of these ethical principles beneficence and nonmaleficence are strengthened by state nursing practice acts, which mandate that nurses are legally obligated to safeguard patients and the profession (Bjarnason & LaSala, 2011). Furthermore, it is with great purpose that we discuss the two principles beneficence and nonmalficence and their importance to the nursing profession. The principle of beneficence is concerned with a moral obligation to act for the benefits of others (Kennedy, 2004). Additionally, beneficence is the principle consisting of deeds such as mercy, kindness, and charity (Rich, 2008). There are other forms of beneficence including altruism, love, and humanity (Beauchamp & Childress, 2009). We use beneficence in order to cover beneficent actions more broadly, so that it includes all forms of action to benefit other persons (Beauchamp & Childress, 2009). Overall, beneficence implies that an individual takes action to do good by benefiting others and facilitating their well-being. Beneficence also requires that benefits are balanced against risks and costs (Kennedy, 2004). In order for a person to â€Å"do good†, they must also consider the values of individual in question (Bjarnason & LaSala, 2011). Health care professionals have a duty t... ...ey encounter an ethical dilemma (Rich, 2008). Nurses can also periodically be called to an ethics committee to consult to gain access to needed help to resolve ethical dilemmas. Serving on an ethics committee with other disciplines and discussing the ethical dilemmas brought before the committee can be an informing and challenging process for a nurse (Lachman, 2010). Furthermore, the opportunity to help patients, staff, and families resolve these dilemmas is professionally rewarding for a nurse (Lachman, 2010). Overall, ethical dilemmas are faced every day in the clinical practice of nurses. When facing an ethical dilemma, remembering to preserve the patient's autonomy, dignity and rights is an important part of ethically solving the dilemma. However, if the ethical dilemma cannot be resolved nurses have the right to seek advice from other professionals. â€Æ'