The Theories of Maugham and Woolf free essay sample

Presents the literary perspectives of Somerset Maugham and Virginia Woolf on the purpose of human existence This paper is a comparative analysis of W. Somerset Maughams novel Of Human Bondage and Virginia Woolfs book To the Lighthouse. The author explains how each work presents a unique perspective on the purpose of the human existence evidenced through an assessment of literary approaches and biographical influences. Also considered are the literary styles, outlooks towards death and main characters. The history of English literature can be said to resemble the lineage of a family tree. As generations pass, innovative ideologies are birthed and literature offshoots into new schools of thought. While each green branch is unique in its own right, it is also indebted to all those that came before. Hence, in this way no writer is ever wholly inventive or original. Consequently, authors Virginia Woolf and W. Somerset Maugham have more in common than either would admit to. We will write a custom essay sample on The Theories of Maugham and Woolf or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page

Written Assignment On A Case Study-Rangan, V. K., Yong, S. (2011,

Written Assignment On A Case Study-Rangan, V. K., Yong, S. (2011, Written Assignment On A Case Study Coracle Marketing al affiliation Coracle Marketing Soren chemical deals with water purification and swimming pool cleaning. Theyhave a new product Coracle that they have introduced to the market. Their initial product, Kailan MW performed so well, and they required something that was specific to small pools. It called for the introduction of Coracle washing chemical. However, they had a poor get-to-market strategy that dealt them a blow in terms of sales. Their distribution strategy was the business to business model. It meant that they had no direct access to the consumer. The main distribution channel partners were the wholesalers and retailers. The wholesalers would buy and sell to the retailers who had direct access to the consumer. However, a few chemical companies could sell directly to Wal-Mart, but it was expensive for small chemical companies. The packaging needs to be up to standard and have it as a product of its own. The marketing strategy should change and target the con sumer and not the wholesaler. Therefore, the distribution channel should change at least in the first few months. Getting directly to consumers will help in getting substantial feedback. We get from wholesalers and retailers may be altered to cater for their interests. As wholesalers care more about their margins, a direct consumer can advise on how the product should be adjusted to fit his or her needs. It would give a direct basis of the alteration of the products chemical composition to fit the customer need. It eases marketing costs. While launching a product, it is fundamental to reach the actual consumer since they offer information on how improvements should happen. The supplier scorecard is a powerful tool for customers to give feedback and make manufacturer improve over time (Hill, 2012).ReferenceHill, A. (2013). An Encyclopedia of Operations Management: A Field Manual and Glossary of Operations Management Terms, and Concepts. Upper Saddle River, N.J.: FTPress Delivers.

The psychological effects of people with intellectual disabilities Dissertation

The psychological effects of people with intellectual disabilities experiencing loss and bereavement - Dissertation Example This girl of 19 years and very dependent on her mother was not allowed to come anywhere near her mother’s body before she was taken away. She was being continually picked upon and that left her irritated and lost. The bereavement could not be handled by this girl and the attitude of her aunt made her worse. The community as a whole did not know how to handle grief associated with bereavement. The psychological responses such as yearning, anxiety, depression, distrust of others and complicated grief were expected of the intellectually disabled. Carers and staff were not prepared to recognise or to provide effective support at the time of loss and bereavement. Their ignorance of how to handle the situation could be the main culprit. Searching through the literature, I was surprised to find that little empirical research had been done to specifically look at the normal or complicated grief response in people with learning disabilities. On a personal level the subject is of great interest to me and it is intended that this research will increase my knowledge in theory and practice as well as enhancing the importance of research to my continuing professional development. History My search took me to the university Library. Electronic search engines and databases were looked through. PSYC INFO, CINAHL, PUBMED and the COCHRANE electronic databases helped me gather some material pertaining to the subject. The keywords used were bereavement, psychological reactions, loss, complicated grief, grief and learning disabilities. The Learning Resource Centre (LRC) library, Department of Health and Rowntree Foundation website helped me to retrieve grey literature. Boolean operators were used to narrow the results. Combined randomised controlled trials of bereaved adults with learning disabilities that compared community based interventions were included in the review. Life events with its psychological problems that were emotional, psychiatric and behavioural responses t o bereavement were also included. Recognition and concept of death by people with learning disabilities and their families and carers, as well as inclusion of assessment tools of complicated grief were selected. The exploration of support and interventions were also collected. A number of recent articles had considered the implications of grief and bereavement for people with learning disabilities. This had influenced me to concentrate on the parameters of the years between 2002 and 2010. Because of limited empirical studies I have included some of the articles with case studies illustrations. With eleven journal articles, I was ready to start on my hunt for ways of managing complicated grief in intellectually disabled persons. Could I be signalling off a process which has the outcome of the improved welfare and quality of life of the intellectually disabled at heart where bereavement grief is concerned? Critique of two articles on data collection and analysis Dodd, P., Guerin, S., McEvoy, J., Buckley, S., Tyrrell, J. & Hillery, J. (2008). A study of complicated grief symptoms in people with intellectual disabilities. Journal of Intellectual Disability Research, 52 (5), 415-425. The data were contained in the two assessment tools used for this study: Complicated Grief Questionnaire for People with Intellectual Disabilities (CGQ- ID) and Bereavement History Questionnaire (Adapted). The tools had been described

Assignment Example | Topics and Well Written Essays - 1000 words - 69

Assignment Example Fed can purchase government either securities or lowers current reserve rations. In doing so, interest rates will fall and hence bringing the economy back to full employment. Suppose on observing that there is excess money supply in the economy, Fed will use open market operations to try to reduce the excess supply. Sales of government securities contract the assets accessible to lend and tend to increase the federal funds rate. Policymakers call this contractionary monetary policy or tightening. The Fed is targeting an interest rate level that would enable it achieves and controls its goal for employment. Economic growth, interest rate stability, and inflation can hit this rate target by choosing an appropriate value of money supply that will equate to money for equilibrium conditions in the capital market. The sale of government securities leads to a decrease in money supply from MS1 to MS2 in the economy. As a result, the current reserve ratio increase and hence putting an upward pressure on the Fed interest rate (Setterfield 105-116). Therefore, contracting policy results in the increase in interest rates from R1 to R2 and hence the cost of borrowing from commercial banks increases discouraging borrowing. When Fed sells government securities, it reduces money supply in the economy. The fall in money supply results in an increase in interest rates to R2. The increase in the interest rates reduces the level of aggregate demand and investment to I2 and hence a reduction in real GDP. As soon as the economy is in the recessionary gap, the Fed will implement an expansionary monetary policy to upsurge money supply in the market through three monetary policy instruments. By buying government securities and bonds, the Fed target will be to reduce the interest rate level. Moreover, it can lower the reserve rate or lessen the discount rate. The move will lead to a reduction in lending rates; hence, commercial banks will be encouraged borrowing

According to Nietzsche, what did good and bad originally man in early Essay

According to Nietzsche, what did good and bad originally man in early heroic Western society Who (according to Nietzsche) re-valued this original meaning and changed it into good and evil What - Essay Example That is, ‘good’ was linked with the superior, privileged and noble, whereas ‘bad’ was linked with the common low and working-class (Guay, 96). Nevertheless, the offspring of the low class started resenting being inferior; they started resenting being ‘bad.’ Their hatred towards the upper-class led to a â€Å"radical changing of their ideals. Meaning ‘good’ and ‘bad’ started to reverse in meaning so that now ‘good’ defined the common, poor low, and inferior, whereas ‘bad’ now was for the powerful, rich, privileged and superior. In this manner, the deprived, sick, helpless and poor became virtuous, whereas the superior, noble and wealthy became wicked (Guay, 96). This transformation of values is likely when the hatred of the lesser classes for the powerful turns out to be so huge that they get reparation just in imagining or building a diverse moral system. It is this building of a contrasting moral system that is referred by Nietzsche as the slave morality. Thus, so that the powerless can have a better feeling of the circumstances that they are in, they build a morality for themselves, which is a slave morality, where the lesser are ‘good’ while the dominant are ‘evil.’ Nietzsche expresses his dissatisfaction with the psychologists who have attempted to give the origin of morality. They say that they are historians of morality; however they do not have a historical spirit. Their theories propose that originally individuals gain from altruism actions of others would applaud the actions and refer to them as ‘good.’ That means, what was initially ‘good’ and useful were taken as one and the same. With time, the genealogists propose, that the original association be forgotten, and the habit of referring to altruism actions ‘good’ resulted to the conclusion that they were somehow good of and in themselves (Guay, 97). Nietzsche does not agree with this account. He

Paul Hindemith Sonata For Flute And Piano Film Studies Essay

Paul Hindemith Sonata For Flute And Piano Film Studies Essay J.S.Bach: Sonata in G minor, for flute and obbligato harpsichord. In a famous remark about J.S.Bach, Beethoven said he should be named Sea instead of Bach, because of his infinite, inexhaustible wealth in tone combinations and harmonies. These virtues are also deployed in his flute sonatas, each with a unique melodic contour and character. Bach was often criticized for being abstruse and redundantly complex, but he was able to prove through his work that he was, and would remain, a great pioneer. The special importance of his chamber music, in which he demonstrated a deep knowledge of the typical idioms and performing techniques of each instrument, was recognized at a very early age. Bach is generally described as a rather austere personality, but that may be the result of a lack of information complementing his character, deemed unfitting for archival storage. The first use of the transverse flute in Bachs works was in Cantata no 137a, performed in 1722, in Cà ¶then for the birthday of Prince Leopold, with whom Bach maintained very good relations. Many significant works, such as the first book of the well-tempered Clavier, cello suites and probably some of the flute sonatas (they are dated between 1720 and 1741), were also composed during the time he spent there, exploiting the qualities and extended experience attained at the Weimar court. It was a period when the transverse flute, technically more advanced, began gaining ground against its rival, the recorder, and when J.Quantz started making it widely famous. The flutists of that era seemed to manifest a particular dexterity, equivalent to that, required not only in the flute sonatas, but also in other flute parts of many of the composers works, such as the cantatas and passions. In one of Bachs biographies, published in 1802, by Forkel, the latter states that the flute sonatas even in our days†¦would be heard by connoisseurs with pleasure. This particular work raises a controversial issue about its paternity. Bachs authority regarding the piece started to become questioned during the third decade of the 20th century. Scholars expressed certainty that Bachs son, Carl Phillip Emmanuel, is the composer of this sonata (the dominant consensus today), but until today, no assumption has been unquestionably proved and no explanation has been given as to why an aspiring composer like C.P.Emanuel would attribute this work to his father without any plausible reason. A recent study, by Keiichi Kubota, speculates that the g minor sonata is the result of a collaborative work between Bach and his son (the latter ascribing authority to his father). The sonata is played today by both violinists and flutists, as it is believed that the piece may have been written initially for violin, as supported in many published articles. Its form is that of the Italian concerto, lively-slow-lively, which reminds the listener of the significant influence of Vivaldi and Italian music to Bach. G.Faurà ©: Fantaisie pour flute et piano, op. 79 Flute has always been associated with France, a relation that is firmly built upon the particular interest of French composers and performers in this technically developed instrument, especially around the turn of the 19th century. Paris stood in the forefront of musical processes at the time, and served as an incubator for new composers and performers, who formed the new trends. Gabriel Faurà ©, a composer, organist, pianist, choirmaster and teacher, is one of the most important French figures of the turn of the 20th century, characterized by Debussy as the master of charms. He was fortunate enough to be a student and later friend of Saint-Saà «ns, at the Ecole Niedermeyer, where he was sent, after his father realized the unique talent of his son. His style, multi-faceted and resourceful, continued to evolve until the composers death, in 1924. For that reason, putting labels on Faurà ©s music can never be precise. His artistic hallmark is regarded as the bridge between Romanticism and Modernism and at the time of his death the second Viennese School was beginning to emerge. He was always self-critical (to the extent of discarding some of his already composed work) and pursued unremitting productiveness. His harmonic and melodic creativeness paved the road for new musical trends and made his style an inextricable element of future teaching of harmony and composition. Faurà © composed the Fantaisie for flute and piano, in 1898, upon a commission from his friend and colleague, P.Taffanel, who was a professor at the Conservatoire of Paris, and to whom the piece is dedicated (later Faurà © would be appointed director of the Conservatoire). This piece was to be used for the annual introductory exams (Concours). Faurà ©, being among the first composers to be commissioned for the morceau de concours, confessed to Saint-Saà «ns in a letter, that this piece constituted a real challenge for him. He sent it to Taffanel asking him to amend any parts that were not appropriate for the flute. Faurà © incorporated the Andante of the Fantaisie to his incidental music, performed in London for the Maeterlinks play, Pellà ©as et Mà ©lisande. This piece, which is dedicated to Taffanel, sets out to explore flutes full potential, by extending to all three registers, covering all of the Romantic instruments range. The performer is required to demonstrate wealth and diversity in his expression and sound, in his effort to trace the unfolding melody. Observation of the piano part reveals the prominence of the instrument in Faurà ©s mentality. It is perceived not merely as an accompanying instrument, but rather as an equal partner, contributing to the melodic and rhythmic development of the piece. Together with the flute they make use of an extensive expressional quiver, alternating staccatos with long legato phrases, as after a sicilienne-like introduction, an increasing complexity in the instruments parts is combined with sudden dynamic changes. Fantasia also exists in an orchestral version. This was realized later, after the composer death, by Louis Aubert, in 1957, at the request of the prominent French flutist, Jean Pierre Rampal. Paul Hindemith sonata for flute and piano (1936) In Hindemiths opera Mathis der Mahler, Grà ¼newald, a painter, realizes that he should never have betrayed his art for the sake of political activism. Hindemith though, never betrayed his versatile artistic personality and established a prominent career both as a performer and composer, demonstrating a manifold expressiveness. He aspired to create a new mentality in music, but not as an end in itself. The term Gebrauchsmusik (functional music) refers to his notion for music, which should be created to serve a purpose, because the days of composing only for the sake of composing were perhaps gone forever. By drawing on multiple styles and forms he explored all aspects of resourcefulness and complexity. His activity was not restricted only to the production of music, but he also took up a dynamic role as a tutor which is colligated with his series of simple works for children and amateurs. His theoretical treatise Unterweisung im Tonsatz, sets the basis for a new approach towards harmony and melodic shaping and the views expressed would influence the next generations of composers. Hindemith lived in an era of political turmoil and his revolutionary style could not have evaded Nazis attention, who deemed his music as Gà ¶bbels put it pure noise-making. Although Hindemith was naive enough to ignore (at the beginning at least) the Nazi threat, his sonata for flute and piano, composed in 1936, has incorporated this aspect, yielding a work that alludes to this sinister political environment and asserting the composers belief that an artist cannot remain untouched by the human suffering around him. The flute sonata was composed at a time of an increasing awareness by Hindemith of the looming danger and the subsequent need to flee his country. His emotional disposition is adumbrated in the second movement which conveys a suffering through its recitativo-like melody of the flute. One cannot fail to notice the fine irony emanating from the sonatas strict rhythmic form which dissolves into a childish-like melody, projecting the image of a child imitating a soldiers march. Hindemith, tried to capture the vanity of human arrogance in conjunction with the suffering and desperation. The flutist is required to render a wide palette of colors and emotions, from triumphant marches to bleak moments of agony and melancholy, by extending to the full range of the instrument. The piano has an emancipated part in the sonata and continuously moves in a contrapuntal way against the flute, hence sometimes its preferred with its lid open. The boundaries between minor and major chords and atonal parts become blurred, much as the boundaries between life and death at the time of the composition, the death which Hindemith eluded only by chance in multiple occasions.

Ecstasy, the Brain, and the Media :: Drugs Drug Chemistry Essays

Ecstasy, the Brain, and the Media Ecstasy has been glorified by countless Brit-pop drug anthems, condemned by staunch anti-drug foundations and even caused a controversial media debate when the post-mortem picture of eighteen year old Lorna Spinks was splashed across every newspaper in the United Kingdom, her Ecstasy-related death rendered in full gruesome color. The long-term effects and temporary consequences of Ecstasy have been a subject of heated debate in the past ten years as the pill has seen a surge in popularity. What exactly does Ecstasy do to the brain? What creates the euphoric effects? Why has it been used in therapy? And does the media's portrayal of Ecstasy rely on the facts of the drug, or skew the information to instill a sense of fear into citizens, parents, and teenagers? Ecstasy (Methlenedioxy-methamphetamine, MDMA for short) is a synthetic, psychoactive drug with amphetamine-like and hallucinogenic properties. It shares a chemical structure with methamphetamine, mescaline, and methylenedioxyamphetamine (MDA), drugs known to cause brain damage (1). MDMA, in a simple explanation, works by interfering with the communication system between neurotransmitters. Serotonin is one of a group of neurotransmitters that carries out communication between the body and the brain. The message molecules travel from neuron to neuron, attaching to receptor sites. This communication activates signs that either allow the message to be passed or prevent the message from being sent to other cells. However, when MDMA enters the nervous system, it interferes with this system. After serotonin is released, the neurotransmitters are retrieved into the nerve terminal where they are recycled. MDMA hinders this process so that the serotonin is not drawn back in. This allows for an accumulation of serotonin, and also an increase in serotonin synapses (2). This surge of serotonin creates an emotional openness in the Ecstasy user. A sense of euphoria and ecstatic delight envelop the user. Some users report thinking clearly and objectively, and often claim to come to terms with personal problems or various other skeletons in the closet (3). This is the reason Ecstasy resurfaced in the 1980s (after being developed in Germany in 1912 as a dieting drug due to the fact that amphetamines are appetite suppressors) as a tool in experimental psychotherapy, particularly regarding relationship and marital problems (4). In 1984 the drug was declared illegal in the United States after it started being used for recreational purposes. However, in June of 1999, Swiss courts ruled that dealing Ecstasy is not a serious offence.

Metabolism

Now that you are familiar with the structure of prokaryotic cells, we can discuss the activities that allow these microbes to thrive. The life support activity of even the most structurally simple organism involves a large number of complex biochemical reactions. Most, although not all, of the biochemical processes of bacteria also occur in eukaryotic microbes and in the cells of multicellular organisms, including humans. However, the reactions that are unique to bacteria are fascinating because they allow microorganisms to do things we cannot do (Neidhardt & Holde, 1990). For example, some bacteria (the chemoautotrophs) can grow on diets of such inorganic substances as carbon dioxide, iron, sulfur, hydrogen gas, and ammonia.This paper examines some representative chemical reactions that either produce energy (the catabolic reactions) or use energy (the anabolic reactions) in microorganisms. We will also look at how these various reactions are integrated within the cell.II. Discussio nA. Catabolic and Anabolic ReactionsWe use the term metabolism to refer to the sum of all chemical reactions within a living organism. Because chemical reactions either release or require energy, metabolism can be viewed as an energy-balancing act. Accordingly, metabolism can be divided into two classes of chemical reactions—those that release energy and those that require energy. In living cells, the chemical reactions that release energy are generally the ones involved in catabolism, the breakdown of complex organic compounds into simpler ones. These reactions are called catabolic, or degradative, reactions.On the other hand, the energy-requiring reactions are mostly involved in anabolism, the building of complex organic molecules from simpler ones. These reactions are called anabolic or biosynthetic reactions (Neidhardt & Holde, 1990). Anabolic processes often involve dehydration synthesis reactions (reactions that release water) and require energy to form a new chemical b onds.Examples of anabolic processes are the formation of proteins from amino acids, nucleic acids from nucleotides, and polysaccharides from simple sugars. These biosynthetic reactions generate the materials for cell growth. Catabolic reactions are generally hydrolytic reactions (reactions that use water to break chemical bonds). Chemical bonds store energy; when they are broken, chemical energy is released. An example of catabolism occurs when cells break down sugars into carbon dioxide and water.Catabolic reactions furnish the energy needed to drive anabolic reactions. This coupling of energy-requiring and energy-releasing reactions is made possible through the molecule adenosime triphospahte (ATP). ATP stores energy derived from catabolic reactions and releases it later to drive anabolic reactions and perform other cellular work. A molecule of ATP consists of an adenine, a ribose, and three phosphate groups.When the terminal phosphate group is split from ATP, adenosine diphosphat e (ADP) is formed, and energy is released to drive anabolic reactions. Using P to represent a phosphate group, we can write this reaction as (ATP—> ADP + P + energy). Then, the energy from catabolic reactions is used to combine ADP and a P to resynthesize ATP (ADP + P + energy—> ATP).Thus, anabolic reactions are coupled to ATP breakdown, and catabolic reactions are coupled to ATP synthesis. This concept of coupled reactions is very important. For now, you should know that the chemical composition of a living cell is constantly changing; some molecules are being broken down while others are being synthesized. This balanced flow of chemicals and energy maintains the life of a cell (â€Å"Metabolism; What is it exactly and how fast or slow should it be?†).B. EnzymesChemical reactions occur when chemical bonds are formed or broken. In order for reactions to take place, atoms, ions, or molecules must collide. Whether a collision produces a reaction depends on the spe ed of the particles, the amount of energy required to trigger the reaction (called activation energy), and the specific configuration of the particles. The physiological temperature and pressure of organisms are too low for chemical reactions to occur quickly enough to maintain the life of the organism.Raising the temperature and pressure and the number of reacting molecules can increase the frequency of collisions and the rate of chemical reactions. However, such changes could damage or kill the organism. The living cell’s solution to this problem is a class of proteins called enzymes. Enzymes can speed up chemical reactions in several ways. For example, an enzyme may bring two reactant molecules close together and may properly orient them to react. Whatever the method, the result is that the enzyme lowers the activation energy for the reaction without increasing the temperature or pressure inside the cell (â€Å"Immobilized Enzymes Can Check Bioterrorism, 2003).Substances that can speed up a chemical reaction without themselves being altered are called catalysts. In living cells, enzymes serve as biological catalysts. As catalysts, enzymes are specific. Each acts on specific substance, called the enzyme’s substrate (or substrates when there are two or more reactants), and each catalyzes only one reaction. For example, sucrose (table sugar) is the substrate of the enzyme sucrase, which catalyzes the hydrolysis of sucrose to glucose and fructose.The specificity of enzymes is made possible by their structures. Enzymes are generally globular proteins that range in molecular weight from about 10,000 to several million. Each of the thousands of known enzymes has a characteristics three-dimensional shape with a specific surface configuration as a result of its primary, secondary, and tertiary structures. The unique configuration of each enzyme enables it to â€Å"find† the correct substrate from among the large number of diverse molecules in t he cell (â€Å"Immobilized Enzymes Can Check Bioterrorism, 2003).C. Factors Influencing Enzymatic ActivitySeveral factors influence the activity of enzyme. Among the more important are temperature, pH, substrate concentration, and inhibitors.a.) TemperatureThe rate of most chemical reactions increases as the temperature increases. Molecules move more slowly at low than at higher temperatures and may not have enough energy to cause a chemical reaction. For enzymatic reactions, however, elevation beyond a certain temperature drastically reduces the rate of reaction. This decrease is due to the enzyme’s denaturation, the loss of its characteristics three-dimensional structure (tertiary configuration). Denaturation of a protein involves breakage of hydrogen bonds and other noncovalent bonds (Neidhardt & Holde, 1990).Most enzymes have a pH optimum at which their activity is characteristically maximal. Above or below this pH value, enzyme activity, and therefore the reaction rate, declines. When the H+ concentration (pH) in the medium is changed, many of the enzyme’s amino acids are affected and the protein’s three-dimensional structure is altered. Extreme changes in pH can cause denaturation (Neidhardt & Holde, 1990).Substrate ConcentrationThere is a maximum rate at which a certain amount of enzymes can catalyze a specific reaction. Only when the concentration of substrate(s) is extremely high can this maximum rate be attained. Under conditions of high substrate concentration, the enzyme is said to be saturated; that is, its active site is always occupied by substrate or product molecules. In this condition, a further increase in substrate concentration will not affect the reaction rate because all active sites are already in used. If a substrate’s concentration exceeds a cell’s saturation level for a particular enzyme, the rate of reaction can be increased only if the cell produces additional enzyme molecules (Neidhardt & Holde, 1990). However, under normal cellular conditions, enzymes are not saturated with substrate (s). At any given time, many of the enzyme molecules are inactive for lack of substrate; thus, the rate of reaction is likely to be influenced by the substrate concentration.InhibitorsAn effective way to control the growth of bacteria is to control their enzymes. Certain poisons, such as cyanide, arsenic, and mercury, combine with enzymes and prevent them from functioning. As a result, the cells stop functioning and die.Enzyme inhibitors are classified according to their mechanism of action as competitive inhibitors and noncompetitive inhibitors. Competitive inhibitors fill the active site of an enzyme and compete with the normal substrate for the active site. The competitive inhibitor is able to do this because its shape and chemical structure are similar to those of the normal substrate.Noncompetitive inhibitors do not compete with the substrate for the enzyme’s active site; instead they interact with another part of the enzyme. In this process, called allosteric (â€Å"other space†) inhibition, an enzyme’s activity is reduced because of a change in shape caused by binding of an inhibitor at a site rather than substrate’s binding site. The change in shape can be either reversible or irreversible (Neidhardt & Holde, 1990).III. ConclusionIn conclusion, the sum of all chemical within a living organism is known as metabolism. Catabolism refers to chemical reactions that result in the breakdown of more complex organic molecules into simpler substances. Catabolic reactions usually release energy. Anabolism refers to chemical reactions in which simpler substances are combined to form more complex molecules. Anabolic reactions usually require energy. The energy of catabolic reaction is used to drive anabolic reactions. The energy for chemical reactions is stores in ATP. Moreover, the enzymes are proteins produced by living cells that catalyze chemi cal reactions. They are generally globular proteins with characteristic three-dimensional shapes.Reference:Neidhardt, F.C. and K.E. van Holde. Biochemistry. Redwood City, Calif: Benjamin/Cummings, 1990. A biochemistry test with chapters on metabolic pathways of energy production and biosynthesis. â€Å"Metabolism; What Is It Exactly and How Fast or Slow Should It Be?† The Washington Times, January 31, 2006. â€Å"Immobilized Enzymes Can Check Bioterrorism.† USA Today (Society for the Advancement of Education), Vol. 131, June 2003 Metabolism The life support activity of even the most structurally simple organism involves a large number of complex biochemical reactions. Most, although not all, of the biochemical processes of bacteria also occur in eukaryotic microbes and in the cells of multicellular organisms, including humans. However, the reactions that are unique to bacteria are fascinating because they allow microorganisms to do things we cannot do (Neidhardt & Holde, 1990). For example, some bacteria (the chemoautotrophs) can grow on diets of such inorganic substances as carbon dioxide, iron, sulfur, hydrogen gas, and ammonia.This paper examines some representative chemical reactions that either produce energy (the catabolic reactions) or use energy (the anabolic reactions) in microorganisms. We will also look at how these various reactions are integrated within the cell.II. DiscussionA. Catabolic and Anabolic ReactionsWe use the term metabolism to refer to the sum of all chemical reactions within a living organism. Because chemical reactions either release or require energy, metabolism can be viewed as an energy-balancing act. Accordingly, metabolism can be divided into two classes of chemical reactions—those that release energy and those that require energy. In living cells, the chemical reactions that release energy are generally the ones involved in catabolism, the breakdown of complex organic compounds into simpler ones.These reactions are called catabolic, or degradative, reactions. On the other hand, the energy-requiring reactions are mostly involved in anabolism, the building of complex organic molecules from simpler ones. These reactions are called anabolic or biosynthetic reactions (Neidhardt & Holde, 1990). Anabolic processes often involve dehydration synthesis reactions (reactions that release water) and require energy to form a new chemical bonds.Examples of anabolic processes are the formation of proteins from amino acids, nucleic acids from nucleotides, and polysaccharide s from simple sugars. These biosynthetic reactions generate the materials for cell growth. Catabolic reactions are generally hydrolytic reactions (reactions that use water to break chemical bonds). Chemical bonds store energy; when they are broken, chemical energy is released. An example of catabolism occurs when cells break down sugars into carbon dioxide and water.Catabolic reactions furnish the energy needed to drive anabolic reactions. This coupling of energy-requiring and energy-releasing reactions is made possible through the molecule adenosime triphospahte (ATP). ATP stores energy derived from catabolic reactions and releases it later to drive anabolic reactions and perform other cellular work. A molecule of ATP consists of an adenine, a ribose, and three phosphate groups. When the terminal phosphate group is split from ATP, adenosine diphosphate (ADP) is formed, and energy is released to drive anabolic reactions.Using P to represent a phosphate group, we can write this react ion as (ATP—> ADP + P + energy). Then, the energy from catabolic reactions is used to combine ADP and a P to resynthesize ATP (ADP + P + energy—> ATP). Thus, anabolic reactions are coupled to ATP breakdown, and catabolic reactions are coupled to ATP synthesis. This concept of coupled reactions is very important. For now, you should know that the chemical composition of a living cell is constantly changing; some molecules are being broken down while others are being synthesized. This balanced flow of chemicals and energy maintains the life of a cell (â€Å"Metabolism; What is it exactly and how fast or slow should it be?†).B. EnzymesChemical reactions occur when chemical bonds are formed or broken. In order for reactions to take place, atoms, ions, or molecules must collide. Whether a collision produces a reaction depends on the speed of the particles, the amount of energy required to trigger the reaction (called activation energy), and the specific configuration of the particles. The physiological temperature and pressure of organisms are too low for chemical reactions to occur quickly enough to maintain the life of the organism. Raising the temperature and pressure and the number of reacting molecules can increase the frequency of collisions and the rate of chemical reactions. However, such changes could damage or kill the organism.The living cell’s solution to this problem is a class of proteins called enzymes. Enzymes can speed up chemical reactions in several ways. For example, an enzyme may bring two reactant molecules close together and may properly orient them to react. Whatever the method, the result is that the enzyme lowers the activation energy for the reaction without increasing the temperature or pressure inside the cell (â€Å"Immobilized Enzymes Can Check Bioterrorism, 2003).Substances that can speed up a chemical reaction without themselves being altered are called catalysts. In living cells, enzymes serve as biolog ical catalysts. As catalysts, enzymes are specific. Each acts on specific substance, called the enzyme’s substrate (or substrates when there are two or more reactants), and each catalyzes only one reaction. For example, sucrose (table sugar) is the substrate of the enzyme sucrase, which catalyzes the hydrolysis of sucrose to glucose and fructose.The specificity of enzymes is made possible by their structures. Enzymes are generally globular proteins that range in molecular weight from about 10,000 to several million. Each of the thousands of known enzymes has a characteristics three-dimensional shape with a specific surface configuration as a result of its primary, secondary, and tertiary structures. The unique configuration of each enzyme enables it to â€Å"find† the correct substrate from among the large number of diverse molecules in the cell (â€Å"Immobilized Enzymes Can Check Bioterrorism, 2003).C. Factors Influencing Enzymatic ActivitySeveral factors influence the activity of enzyme. Among the more important are temperature, pH, substrate concentration, and inhibitors.  a.) TemperatureThe rate of most chemical reactions increases as the temperature increases. Molecules move more slowly at low than at higher temperatures and may not have enough energy to cause a chemical reaction. For enzymatic reactions, however, elevation beyond a certain temperature drastically reduces the rate of reaction. This decrease is due to the enzyme’s denaturation, the loss of its characteristics three-dimensional structure (tertiary configuration). Denaturation of a protein involves breakage of hydrogen bonds and other noncovalent bonds (Neidhardt & Holde, 1990).b.) pHMost enzymes have a pH optimum at which their activity is characteristically maximal. Above or below this pH value, enzyme activity, and therefore the reaction rate, declines. When the H+ concentration (pH) in the medium is changed, many of the enzyme’s amino acids are affected an d the protein’s three-dimensional structure is altered. Extreme changes in pH can cause denaturation (Neidhardt & Holde, 1990).c.) Substrate ConcentrationThere is a maximum rate at which a certain amount of enzymes can catalyze a specific reaction. Only when the concentration of substrate(s) is extremely high can this maximum rate be attained. Under conditions of high substrate concentration, the enzyme is said to be saturated; that is, its active site is always occupied by substrate or product molecules. In this condition, a further increase in substrate concentration will not affect the reaction rate because all active sites are already in used. If a substrate’s concentration exceeds a cell’s saturation level for a particular enzyme, the rate of reaction can be increased only if the cell produces additional enzyme molecules (Neidhardt & Holde, 1990). However, under normal cellular conditions, enzymes are not saturated with substrate (s). At any given time, man y of the enzyme molecules are inactive for lack of substrate; thus, the rate of reaction is likely to be influenced by the substrate concentration.d.) InhibitorsAn effective way to control the growth of bacteria is to control their enzymes. Certain poisons, such as cyanide, arsenic, and mercury, combine with enzymes and prevent them from functioning. As a result, the cells stop functioning and die.Enzyme inhibitors are classified according to their mechanism of action as competitive inhibitors and noncompetitive inhibitors. Competitive inhibitors fill the active site of an enzyme and compete with the normal substrate for the active site. The competitive inhibitor is able to do this because its shape and chemical structure are similar to those of the normal substrate.Noncompetitive inhibitors do not compete with the substrate for the enzyme’s active site; instead they interact with another part of the enzyme. In this process, called allosteric (â€Å"other space†) inhib ition, an enzyme’s activity is reduced because of a change in shape caused by binding of an inhibitor at a site rather than substrate’s binding site. The change in shape can be either reversible or irreversible (Neidhardt & Holde, 1990).III. ConclusionIn conclusion, the sum of all chemical within a living organism is known as metabolism. Catabolism refers to chemical reactions that result in the breakdown of more complex organic molecules into simpler substances. Catabolic reactions usually release energy. Anabolism refers to chemical reactions in which simpler substances are combined to form more complex molecules. Anabolic reactions usually require energy. The energy of catabolic reaction is used to drive anabolic reactions. The energy for chemical reactions is stores in ATP. Moreover, the enzymes are proteins produced by living cells that catalyze chemical reactions. They are generally globular proteins with characteristic three-dimensional shapes.Reference:Neidhard t, F.C. and K.E. van Holde. Biochemistry. Redwood City, Calif: Benjamin/Cummings, 1990. A biochemistry test with chapters on metabolic pathways of energy production and biosynthesis. â€Å"Metabolism; What Is It Exactly and How Fast or Slow Should It Be?† The Washington Times, January 31, 2006. â€Å"Immobilized Enzymes Can Check Bioterrorism.† USA Today (Society for the Advancement of Education), Vol. 131, June 2003

Malaysian Culture Essay

Malaysia has a multi-ethnic, multicultural, and multilingual society. The original culture of the area stemmed from indigenous tribes that inhabited it, along with the Malays who later moved there. Substantial influence exists from Chinese and Indian culture, dating back to when foreign trade began. Other cultural influences include the Persian, Arabic, and British cultures. Due to the structure of the government, coupled with the social contract theory, there has been minimal cultural assimilation of ethnic minorities. Traditional Malaysian art was mainly centred around the areas of carving, weaving, and silversmithing.[181] Traditional art ranges from hand-woven baskets from rural areas to the silverwork of the Malay courts. Common artworks included ornamental kris, beetle nut sets, and woven batik and songket fabrics. Indigenous East Malaysians are known for their wooden masks.[94] Each ethnic group have distinct performing arts, with little overlap between them. However, Malay art does show some North Indian influence due to the historical influence of India. Traditional Malay music and performing arts appear to have originated in the Kelantan-Pattani region with influences from India, China, Thailand and Indonesia. The music is based around percussion instruments, the most important of which is the gendang (drum). There are at least 14 types of traditional drums. Drums and other traditional percussion instruments and are often made from natural materials. Music is traditionally used for storytelling, celebrating life-cycle events, and occasions such as a harvest. It was once used as a form of long-distance communication.[183] In East Malaysia, gong-based musical ensembles such as agung and kulintang are commonly used in ceremonies such as funerals and weddings. These ensembles are also common in neighbouring regions such as in the southern Philippines, Kalimantan in Indonesia, and Brunei. Malaysia’s cuisine reflects the multi-ethnic makeup of its population.[186] Many cultures from within the country and from surrounding regions have greatly influenced the cuisine. Much of the influence comes from the Malay, Chinese, Indian, Thai, Javanese, and Sumatran cultures,[94] largely due to the country being part of the ancient spice route.[187] The cuisine is very similar to that of Singapore and Brunei,[107] and also bears resemblance to Filipino cuisine.[94] The different states have varied dishes,[107] and often the food in Malaysia is different from the original dishes.[142]

Physiology labs essays

Physiology labs essays Properties of the Isolated Mammalian If we were to compare smooth muscle with skeletal muscle we notice that they are very different from one another. Firstly, smooth muscles have a slow cycling of myosin cross bridges as compared to skeletal muscle. However, the fraction of time that the cross bridges remain attached to the actin filaments is believed to be greatly increased in smooth muscle. Secondly, Less energy is required to sustain the same tension of contraction in smooth muscle as in skeletal muscle. Thirdly, The maximum force of contraction of smooth muscle is often even greater than that of skeletal muscle. This great force of smooth muscle contraction results from the prolonged period of attachment of the myosin cross-bridges to the actin filaments. The Gastrointestinal tract has 2 major networks of nerve fibers - Myenteric plexus and the Submucous plexus. The plexuses are interconnected, and they contain motor neurons that innervate the smooth muscle. This is the enteric nervous system. The intestine also receives a dual extrinsic innervation from the autonomic nervous system, with parasympathetic cholinergic activity generally increasing the activity of intestinal smooth muscle and the sympathetic noradrenergic activity generally decreasing it while causing the sphincters to contract. The GI tract is made up of smooth muscles. The individual smooth muscle fibers are between 200 and 500 micrometers in length and 2 and 10 micrometers in diameter, and they are arranged in bundles of as many as 1000 parallel fibers. In general, smooth muscle can be divided into Visceral smooth muscle and Multi-unit smooth muscle. Visceral smooth muscle occurs in large bundles. Within each bundle, the muscle fibers are electrically connected with one another through large numbers of gap junctions that allow low-resistance movement of ions from one cell to the next. Each layer functions as a syncytium; that is, when an action potenti...

Constitutional Law and The Criminal Justice System Coursework

Constitutional Law and The Criminal Justice System - Coursework Example This is more in presenting or challenging the evidences within a meaningful manner. Furthermore, the lawyer helps in maintaining the proper conduct of the defense, in addition to guiding their clients all through the trial in such a manner that the defense is displayed with its complete force plus effect (Harr, Hess, & Orthman, 2012 372). Both sides need to know how to establish their position that is why the presence of the lawyer is significant. Furthermore, given that the responsibility of the lawyer is to take steps for the benefit of another person is a fiduciary relationship, then the presence of the lawyer makes the trial to be fair as it generates particular legal obligations as well as responsibilities (Harr, Hess, & Orthman, 2012 374). Why People Prefer Pro Se Representation People would want to represent themselves in court pro se, mainly for the reason that they have a distrust for lawyers in general. Others believe that they can personally deal with their defense effecti vely, and others will seek to represent themselves owing to their lack of qualification for legal aid and hiring a private lawyer turns out to be expensive (Harr, Hess, & Orthman, 2012 387). ... with complexities, there should be a right to self-representation but this should only be based on the intricacy of the case as well as the formality of the debate (Harr, Hess, & Orthman, 2012 390). Notably, when individuals represent themselves they are accorded the possibility to truly articulate what they feel instead of having their insight filtered through the lawyer. However, when it comes to criminal trials, self representation should not be in place due to the complex nature of the trial process. In complicated trials it is difficult even for the most intelligent and educated citizen to learn the complex aspects of the law, and as a result precise court procedure can be complicated and stressful. Thus, the objective for a lawyer in complicated cases rather than self representation is to safeguard the integrity of the procedure and to guarantee a fair trial (Harr & Hess, 2007 388). Trial by Media Limitation Even though, a public trial advances the fundamental fairness of the t rial as well as the position of fairness when it comes to enhancing public confidence, there has to be a balance between the sixth amendment right of the defendant on one hand and the general public first amendment rights on the other hand (Harr, Hess, & Orthman, 2012 366). Hence, the media is not allowed to attend every trial unless there is a compelling reason in doing otherwise, in particular the safety. The other boundary is when the coverage by the media can cause a worry that the accused will be in danger due to disruption within the court, or the trial becomes somewhat of a three ring spectacle which in the end wipes out the dignified atmosphere as required in court proceedings (Harr, Hess, & Orthman, 2012 366). Barring the Media from Attending Trials This issue of the defendants

Research Proposal Essay Example | Topics and Well Written Essays - 2250 words - 3

Research Proposal - Essay Example Along with the business enterprises, the term has also gained its applicability in social service oriented institutions such as schools, nursing-homes and hospitals. Hence, it is largely differentiated from the other business and social service oriented activities (Dagoon, 2005). With the gradual change in the business scenario, it is quite certain that the global outlook has also changed in terms of Entrepreneurship. Presently, the entrepreneurs have innumerable opportunities rewarded by the economy such as technology, flexible policies for global trade, and increasing demand. But there are also few major challenges that entrepreneurs need to face while creating a new business idea and serve it to the ultimate customers. Few of them are high level of competition, constantly increasing demand for innovations, rigidity of government norms like taxation and others. Moreover, as it depends highly on the issue of personal perceptions and the environmental influences of the entrepreneurs, the applicability of entrepreneurship also differs from one economy to other and from one business to another (Viramgami, 2007). Hence, this paper shall concentrate on the aim to understand the modern day phenomenon of entrepreneurship in two different countries, India and the United Kingdom. As these economies are largely different in terms of both social and economic attributes it shall be beneficial to critically analyse the entrepreneurial process. Moreover, the proposed paper shall centre on the business sector comprising of entrepreneurial process related to the petrol station-cum- convenience store. The paper shall try to conclude on the aspect of development of entrepreneurship in both these economies with the help of wide ranging researches. With a growing emphasis on the term ‘Entrepreneurship’, several theorists and analysts have stated their viewpoint in various literatures and research papers. These are beneficial to critically evaluate the meaning of the term. In